Curriculum Vitae Heinrich Jasper, Ph.D. Associate Professor Department of Biology University of Rochester River Campus Box 270211 Rochester, NY 14627 Phone: (585) 275 8973 Fax: (585) 275 2070
[email protected] Personal Data:
Birthday: Nationality: Marital Status: Languages: Home Address:
February 1, 1974 German Married, three children German, Spanish, English 70 Branford Road, Rochester, NY 14618, USA
Degrees: October 2002
Ph.D. in Biology, ‘summa cum laude’, University of Heidelberg, Germany.
December 1998
Diploma in Biochemistry, ‘sehr gut’, University of Tübingen, Germany.
Education and Professional Experience: July 2010 – present
Associate Professor (tenured), Department of Biology, University of Rochester (Rochester, NY, USA).
2005 - 2010
Assistant Professor, Department of Biology, University of Rochester (Rochester, NY, USA).
2003 – 2005
Research Assistant Professor, Department of Biomedical Genetics, University of Rochester Medical Center (Rochester, NY, USA).
2001 – 2002
Researcher, University of Rochester Medical Center (Rochester, NY, USA).
1999 – 2002
Ph.D. Thesis, European Molecular Biology Laboratory (EMBL) and University of Heidelberg (Heidelberg, Germany). Supervisor: Dr. Dirk Bohmann. “Analysis of signaling and cell differentiation events in Drosophila development by genome-wide expression profiling.”
1998
Diploma Thesis, Friedrich Miescher Laboratory of the Max-Planck-Society (Tübingen, Germany). Supervisor: Dr. Ralph A.W. Rupp. “Identification of target genes of the myogenic transcription factor MyoD in Xenopus laevis.”
1996 – 1997
Research Student, Max Planck Institutes of Biochemistry and Neurobiology (Munich, Germany).
1994 – 1996
Laboratory Assistant in Dr. R.A.W. Rupp’s laboratory, Friedrich Miescher Laboratory of the Max-Planck-Society (Tübingen, Germany).
1993 – 1998
Student, Biochemistry Program, University of Tübingen (Tübingen, Germany).
1992
Abitur (German High School Diploma), Alexander von Humboldt - School (Lima, Peru).
Heinrich Jasper, Ph.D.
Honors and Awards:
Glenn Foundation Award for Research in Biological Mechanisms of Aging (2010) Wilmot Assistant Professorship in Arts, Sciences and Engineering 2009 The Ellison Medical Foundation: Senior Scholar Award in Aging 2008 Predoctoral Fellowship from the Deutsche Forschungs Gemeinschaft (DFG) at the University of Heidelberg and EMBL (1999 – 2001)
Teaching:
Course director BIO 215/415/215w, “Molecular Biology of Cell Signaling”, Spring 2007, 2008, 2009, 2010 (overall course rating 4.04, overall instructor rating 4.15) Course director BIO 516 “Current Biology Seminar for graduate students”, Fall 2008 Bio 228 “Development Lab”, 3 weeks in Fall 2006, 2007 Guest lecture in Bio 222 “Biology of Aging”, Fall 2005 - 2009 Guest lectures in Bio 228 “Development Lab”, Fall 2005 Instructor, GEN 508 “Genes, Development and Disease” Spring 2003 - 2005 Instructor, EMBO Practical Course “Genome Analysis by High Throughput Techniques”; EMBL (Heidelberg, Germany), December 2000
Publications, peer reviewed: Biteau, B., Karpac, J., Supoyo, S., DeGennaro, M., Lehmann, R., Jasper, H. (2010) “Lifespan extension by preserving proliferative homeostasis in Drosophila.” PLoS Genetics, in press. Karpac, J., Hull-Thompson, J., Falleur, M., Jasper, H. (2009) “JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila.” Aging Cell; 8: 288-295. Hull-Thompson, J., Muffat, J., Sanchez, D., Walker, D., Benzer, S., Ganfornina, M.D., Jasper, H. (2009) “Control of metabolic homeostasis by stress signaling is mediated by the Lipocalin NLaz.” PLoS Genet. 5(4):e1000460. Epub 2009 Apr 24. Damgaard-Nielsen, M., Luo, X., Biteau, B., Syverson, K., Jasper, H. (2008) “143-3epsilon antagonizes Foxo to control growth, stress tolerance and longevity in Drosophila.” Aging Cell 7(5):688-99. Epub 2008 Jul 28. Biteau, B., Hochmuth, C.E., Jasper, H.(2008) “JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut.” Cell Stem Cell. 3(4):442-55. Luo, X., Puig, O., Hyun, J., Bohmann, D., Jasper, H. (2007) “Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation.” EMBO Journal 26:380. Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D. (2006). “JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.” Developmental Dynamics, 235: 427-434. Etter PD, Narayanan R, Navratilova Z, Patel C, Bohmann D, Jasper H. & Ramaswami M. (2005). “Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons.” BMC Neurosci. 6:39.
2
Heinrich Jasper, Ph.D.
Uhlirova, M., Jasper, H. & Bohmann, D. (2005). “Non Cell-Autonomous Induction of Tissue Overgrowth by JNK/Ras Cooperation in a Drosophila Tumor Model.” Proceedings of the National Academy of Sciences, 102:13123-13128. Hyun, J., Jasper, H. & Bohmann, D. (2005). “DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.” Molecular and Cellular Biology, 25: 5590-5598. Wang, M.C., Bohmann, D. & Jasper, H. (2005). “JNK extends lifespan and limits growth by antagonizing cellular and organism-wide responses to Insulin signaling.” Cell 121: 115-125. Wang, M.C., Bohmann, D. & Jasper, H. (2003). “JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.” Developmental Cell, 5: 811-816. Jasper, H., Benes, V., Atzberger, A., Sauer, S., Ansorge, W., Bohmann, D. (2002). “A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye.” Developmental Cell 3: 511-521. Jasper, H., Benes, V., Schwager, C., Sauer, S., Clauder-Münster, S., Ansorge, W., Bohmann, D. (2001). “The Genomic Response of the Drosophila Embryo to JNK Signaling.” Developmental Cell 1: 579-586. Nayler, O., Straetling, W., Bourquin, J.P., Stagljar, I., Lindemann, L., Jasper, H., Hartmann, A.M., Fackelmayer, F.O., Ullrich, A. and Stamm, S. (1998). "SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements." Nucleic Acids Research 26: 3542-3549. Book Chapter:
Jasper, H. (2005). “Using SAGE to analyze signaling and development in Drosophila.” in “SAGE: Current Technologies and Applications.” Wang, S.M., editor. (Horizon Scientific Press, Norfolk, UK).
Invited Reviews:
Karpac, J., Jasper, H. Insulin and JNK: optimizing metabolic homeostasis and lifespan.Trends in Endocrinology and Metabolism. Trends Endocrinol Metab. 2009 Apr;20(3):100-6. Epub 2009 Feb 27. Jasper H. (2008).”SKNy worms and long life.” Cell 132: 1. Jasper H. (2006). “Migration in action: profiling border cells.” Developmental Cell, 10:414-415. Jasper, H. & Bohmann, D. (2002). “Drosophila innate immunity: a genomic view of pathogen defense.” Molecular Cell 10: 967-969.
Manuscripts Submitted: Karpac, J., Younger, A., Jasper, H. “Mutual antagonism between inflammatory signaling and Insulin signaling regulates systemic responses to localized DNA damage.” (under review at Developmental Cell). Biteau, B., Jasper, H. “Fos integrates mitogenic and stress signals to control stem cell maintenance and proliferation in the Drosophila intestine.” (under review at Development).
3
Heinrich Jasper, Ph.D.
Luo, X., Damgaard-Nielsen, M., Jasper, H. “Flotillins regulate EGFR and Notch signaling activity to regulate tissue growth and patterning in Drosophila.” (reviewed at PLoS Genetics). Hochmuth, C., Biteau, B., Bohmann, D., Jasper, H. “Redox regulation by Nrf2 is critical for stem cell quiescence in the Drosophila midgut.” (under review at Cell Stem Cell) DeGennaro, M., Biteau, B., Jasper, H., Siekhaus, D., Lehmann, R. “Peroxiredoxin regulation of E-cadherin alters germ cell adhesion.” (under review at Developmental Cell). Jasper, H., Jones, D.L. “Metabolic regulation of stem cell behavior and consequences for aging.” (minireview for Cell Metabolism). Biteau, B., Karpac, J., Hwangbo, D.S., Jasper, H. “Regulation of Drosophila lifespan by JNK signaling.” (Review for Experimental Gerontology).
Research Awards:
1. UCAR/American Federation for Aging Research Jasper (PI)
07/1/04-06/30/05
$50,000
“Regulatory Interactions between JNK and Insulin signaling in the control of life span.” This grant provides funds for genetic studies to characterize interactions between Insulin signaling and JNK signaling in regulating longevity in Drosophila. 2. RO1 AG028127 (Jasper, PI) NIH/DHHS/PHS/NIA
06/01/06–5/31/11 $184,500 (Annual Direct Cost)
“Systemic coordination of stress responses by insulin signaling.” The major goals of this project are to characterize the role of insulin producing cells in coordinating stress responses throughout the organism. The importance of the endocrine regulation of stress responses for stress tolerance and longevity of the organism will be assessed. Furthermore, the control of lipid and carbohydrate metabolism by insulin producing cells and their role in the age-associated decline of metabolic regulation will be analyzed. 3. R01 AG026691 (Bohmann, PI, Jasper Co-PI) NIH/DHHS/PHS/NIA
05/01/06-04/30/11 $184,500 (Annual Direct Cost)
“Cross Regulation Between JNK and Insulin Signaling.” The major goals of this project are to characterize the intracellular crosstalk between the JNK pathway and Insulin receptor signal transduction at the molecular level and to assess the role of this interaction in the control of growth and proliferation. Furthermore, the regulation of autophagy by this interaction will be analyzed.
4
Heinrich Jasper, Ph.D.
4. RO1 EY018177-01A1 (Jasper, PI) NIH/DHHS/PHS/NEI
01/01/08-12/31/10
$150,000 (Annual Direct Cost)
“Regulation of UV-induced apoptosis.” This project intends to characterize the regulation of DNA damage-induced apoptosis in cells of the Drosophila retina. The transcriptional regulation of proapoptotic and protective genes in response to UV irradiation and the integration of stress and survival signaling pathways will be assessed. 5. 1S10RR024577-01 (Jasper, PI) NIH
04/01/2008-03/31/2009
$408,800
Confocal Microscope for University of Rochester Biology Department This is a shared instrumentation grant to purchase a new confocal microscope for the University of Rochester Biology Department. 6. AG-SS-2224-08 (Jasper, PI) Ellison Medical Foundation
10/01/2008-09/30/2012 $150,000 (Annual Direct Cost)
“Tissue regeneration and Aging” The goals of this project are to study the maintenance of stem cell function and tissue regeneration in the aging Drosophila gut. Studies will focus on interactions between stress and Notch signaling and on the characterization of aging-related changes in gene expression in stem cells.
7. N08G-048 (Bohmann, Jasper, Noble, PIs) NYS/DOH (NY State stem cell initiative)
01/01/09-12/31/11 $250,000 (Annual Direct Cost)
“NRF2 as a regulator of stem and progenitor cell function.” The goals of this project are to establish the function of the redox-responsive transcription factor Nrf2 in the regulation of progenitor cell function. The Jasper lab will study the regulation of intestinal stem cell quiescence in Drosophila by the Nrf2 homolog Cnc. Pending Awards:
2R01AG028127-05 (Jasper, PI) NIH/DHHS/PHS/NIA/NIDDK
01/01/11-12/31/15 $250,000 (Annual Direct Cost)
“Systemic Coordination of stress response by insulin signaling” This is a renewal of RO1 AG028127, scored at the 4.0 percentile, Council review pending. The major goals of this project are to characterize endocrine signaling interactions that regulate the systemic response to localized genotoxic insults and to assess how these signaling interactions govern tissue homeostasis and lifespan in the fly. R01AG039498 (Jasper, PI) NIH/DHHS/PHS/NIA/NIDDK
01/01/11-12/31/15
$250,000 (Annual Direct Cost)
“Chronic inflammation and proliferative homeostasis in the aging intestine.” IRG review pending. The goals of this project are to establish the effects of immune senescence in the Drosophila intestine on epithelial homeostasis and lifespan.
5
Heinrich Jasper, Ph.D.
Presentations at Major Professional Meetings: SAGE 2000 Conference “Frontiers in Gene Expression Analysis” Baltimore, MD, September 18-20, 2000 Selected for Oral Presentation SAGE 2001 Conference “Frontiers in Transcriptome Exploration” San Diego, CA, September 8-11, 2001 Invited Speaker EMBL/EMBO Symposium on “Functional Genomics; The Future of Biology” Heidelberg, Germany, October 13-16, 2002 Poster presentation EMBO Workshop “Epithelial Polarity in Development and Disease” Carry-le-Rouet, France, March 27-31, 2004 Poster presentation Expression Array Workshop “From Analysis to Aging” Nathan Shock Center of Excellence in the Basic Biology of Aging Seattle Cancer and Aging Program, University of Washington Seattle, WA, June 24-25, 2004 Invited Speaker International Workshop on current topics in aging research: “The Role of Oxidative Stress/Damage in Aging: Past, Current and Future Research” University of Texas Health Science Center Bandera, TX, October 14-17, 2004 Invited Speaker The 58th Annual Scientific Meeting of The Gerontological Society of America Orlando, FL, November 18-22, 2005 Poster presentation The 47th Annual Drosophila Research Conference Houston, TX, March 29-April 2, 2006 Invited Speaker and Poster Presentation Cold Spring Harbor Conference on the Molecular Genetics of Aging Cold Spring Harbor, NY, October 4-8, 2006 Selected Speaker and Poster Presentation NIH New Investigators Forum The Biology of Aging Program of the NIA San Antonio, TX, May 29-31 2007 Invited Speaker Cell death in Development and Aging
6
Heinrich Jasper, Ph.D.
Institut Biologie Integrative Université Pierre et Marie Curie Paris, France, December 3-4, 2007 Invited Speaker Keystone Symposium: Tumor Suppressors and Stem Cell Biology Vancouver, BC, Canada, February 24-29, 2008 Selected Speaker The sixteenth international workshop on the Molecular and Developmental Biology of Drosophila Kolymbari, Crete (Greece), June 23-28, 2008 Selected Speaker Cold Spring Harbor Conference on the Molecular Genetics of Aging Cold Spring Harbor, NY, September 24-28, 2008 Selected Speaker Molecular Mechanisms of Aging and Age-Related Diseases Puerto Vallarta, Mexico, March 3-6, 2009 Selected Speaker ASBMB Annual Meeting New Orleans, LA, April 18-22, 2009 Invited Speaker Cell/Fondation IPSEN Exciting Biologies Workshop: Biology in Balance Buenos Aires, Argentina, October 8-10, 2009 Selected Speaker German Association of Aging Research (DGfA) Annual Assembly Cologne, Germany, November 6-7, 2009 Invited Speaker Longevity Consortium Symposium LaJolla, CA, December 2-4, 2009 Invited Speaker Cold Spring Harbor Conference on the Molecular Genetics of Aging Cold Spring Harbor, NY, September 29-October 2, 2010 Selected Speaker SFB 497: 4th International Symposium "Signalling Pathways in Stem Cell Biology" Ulm/Germany, October 14-16, 2010 Invited Speaker GSA, 63rd Annual Scientific Meeting New Orleans, LA, November 19-23, 2010 Invited Speaker
7
Heinrich Jasper, Ph.D.
Invited Presentations:
The Huffington Center on Aging Baylor College of Medicine “JNK in Drosophila: Promoting Stress Tolerance and Extending Life” Houston, TX, May 19, 2004 Center for Immunology and Microbial Disease Albany Medical College “Interactions between JNK and Insulin signaling in the control of aging.” Albany, NY, March 28, 2005 IRIC Université de Montréal “Interactions between stress and metabolic signaling in the control of lifespan.” Montreal, Canada, October 31, 2005 Department of Biology New Mexico State University “Systemic regulation of lifespan by JNK signaling.” Las Cruces, NM, September 28, 2006 The Buck Institute “Stress, insulin signaling and lifespan: regulation of metabolic homeostasis and tissue regeneration in aging flies." Novato, CA, July 17, 2009 Basic Biology of Aging Seminar Series University of Washington “Stress, Insulin signaling and Stem Cells: regulating homeostasis in the aging fly.” Seattle, WA, June 22, 2010 2010 Colloquium on the Biology of Human Aging Brown University ““Stress, Insulin signaling and Stem Cells: regulating homeostasis in the aging fly.” Providence, RI, May 24, 2010 Department of Molecular and Computational Biology University of Southern California Los Angeles, CA, December 3, 2010
University presentations: Seminars:
Posters:
Aging day 2005, 2006, 2007 (presented by M.D. Nielsen), 2008 (B. Biteau), 2009, 2010 Genetics day 2009 Science and Technology Seminar Series, Laboratory of Laser Energetics, September 17, 2010 Genetics day 2006: Xi Luo Genetics day 2007: Julie Hull-Thompson Genetics day 2008: Mette D Nielsen Genetics day 2009: Ellen Kelsey, Christine Hochmuth Genetics day 2010: DaeSung Hwangbo, Ellen Kelsey
8
Heinrich Jasper, Ph.D.
Advising / Lab personnel: Graduate Students: Xi Luo (defended 2008) Julie Thompson (defended 2008). Christine Hochmuth DaeSung Hwangbo Ellen Kelsey Debamita Chatterjee Subir Kapuria Post-Docs:
Mette D. Nielsen (funded by the Lundbeck Foundation, Denmark; 2005-2008) Benoit Biteau (funded by the French Cancer Research Association, 2007, and by American Federation for Aging Research; 2008-2009) Jason Karpac (funded by NIH/NIDDK NRSA postdoctoral fellowship F32 DK083862-01; 2009-2011) Susan Tran (2009-) Longze Zhang (2009-)
Technicians:
Olga Dunaevsky (2008-) Nike Detlefsen (2008-2009) Melody Falleur (2007-2008)
Undergraduates:
Keith Syverson (2006) Joe Hatem (2006) Ye (Elaine) Wang (2005-2006) Christopher Hancock (2006-2007) Stephen Supoyo (2008-2009) Andrew Younger (2008-2010) Lena DeBaz (2008-2009) Shufan Sun (2009) Sneha Gupta (2009-)
Rotation Students
(2005): (2006): (2007): (2008):
(2009):
Shanwu Tang Julie Hull-Thompson Li Ka Liu Lidza Kalifa Christine Hochmuth Su Yun Lim DaeSung Hwangbo Nirmalya Chatterjee Amita Vaidya Debamita Chatterjee Subir Kapuria Jorge Azpurua Gurpreet Arora
Departmental and University Committees: 2006: 2007: 2008:
Faculty Search, Seminar (co-chair), Faculty Council Faculty Search (chair), Faculty Council Faculty Search, Graduate Admission and Affairs
9
Heinrich Jasper, Ph.D.
2009: 2010:
Graduate Admission and Affairs Graduate Admission and Affairs, Faculty Search (chair)
Dissertation Advisory Committees: Sonia D'Silva Scott Charette David Loehlin Jeremy Rabinowitz Julie Thompson Xi Luo Dissertation Advisory and Qualifying Examination Committees: Song Shi Jianquan Chen Scott Charette Qiong Wang Yalan Xing Mohammed Rahman Su Jun Lim Pranabananda Dutta Qualifying Examination Committees: Ying Jiang Jeremy Herren Rob Laport Cheng-Chao Lin Biswajoy RayChaudhuri
LiKa Liu Nirmalya Chatterjee Amita Vaidya Rosemary Ryan Xin Yi Chan Victoria Cattani
Reviews for Journals and Funding Agencies: Journals:
Funding agencies:
Cell, Developmental Cell, Developmental Dynamics, Aging Cell, Mol.Cell.Biochem, Biochim.Biophys.Acta, Cell Metabolism, Science, PLOS Genetics, BMC Bioinformatics, Genetics, Genome Biology, Development, PLoS Host and Microbe NIH/NIA review panel for “US-UK Collaborations in the Biology of Aging”, July 2009 NIA program project review panel October 2009 Individual grants for NSF, BBSRC (Great Britain), Dutch Cancer Society (Netherlands)
10
