Example: INTERACTION OF MAOA GENOTYPE, DNA

  Example: INTERACTION OF MAOA GENOTYPE, DNA METHYLATION AND STRESSFUL LIFE EVENTS IN RELATION TO ALCOHOL MISUSE Bendre M1, Checknita D2, Tiihonen J2,3, Hodgins S2,4, Comasco E1, Nilsson KW 5 1) Department of Neuroscience, Uppsala University, Uppsala, Sweden 2) Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden 3) Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden 4) Institut Universitaire en Santé Mentale de Montréal, Université de Montréal 5) Centre for Clinical Research, Uppsala University, County Hospital, Västerås, Sweden Epigenetic mechanisms are candidate mediators of the effects of stressful life events (SLEs) on the brain. Stress, especially during critical developmental periods, might render an individual vulnerable to alcohol misuse later in life. Previous studies report sex-dependent interactions of Monoamine Oxidase A……………………