HyaCare ® Filler CL

January 15, 2018 | Author: Anonymous | Category: Science, Health Science, Pediatrics
Share Embed Donate


Short Description

Download HyaCare ® Filler CL...

Description

HyaCare® Filler CL The topical wrinkle smoother

April 2010

Properties & Features HyaCare® Filler CL is • based on a unique, cross-linked polysaccharide • made from very pure, fermentation-derived hyaluronic acid

• a W/O emulsion containing super-absorbing spherical particles • preservative free

• INCI (proposed): Aqua, Ethylhexyl Stearate, Sodium Hyaluronate Crosspolymer, Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate, Sodium Isostearate, Alcohol

Consumer Specialties | 07/04/2015

Page | 2

Benefits & Claims HyaCare® Filler CL • Instantly fills fine lines & wrinkles • Topical alternative to injectables • Thoroughly hydrates the skin • Increases skin elasticity • Smoothes skin surface

Start

Before application

15 min after application Consumer Specialties | 07/04/2015

Page | 3

Cross-linking in emulsion

HO

OH

COOH O HO O OH

O O NH O

Emulsion Droplets Cross-linking Spherical CL-HA Particles

The average particle size distribution of HyaCare® Filler CL is approx. 700 nm Consumer Specialties | 07/04/2015

Particle size distribution

Page | 4

Water uptake test t = 0 min

t = 30 min

Addition of water to the CL-HA W/O emulsion leads to water uptake

Water is not taken up by a hyaluronic acid W/O emulsion

____20 µm___

HyaCare® Filler CL particles • have super-absorbing properties • show superior water binding Consumer Specialties | 07/04/2015

Page | 5

In vitro enzymatic degradation Test design & result Method: • Measurement of enzymatic cleavage by hyaluronidase • Photometrically quantification by determination of released reducing sugars

HyaCare® Filler CL • is stable against enzymatic degradation • supports longer lasting moisturization

Consumer Specialties | 07/04/2015

Page | 6

In vitro MTT-assay – Test design & result

110,0

++

Method:

100,0

• Cell viability during drying of skin models (SkinEthic) under laminar flow (rel. to vehicle formulation cultivated at RT with plate cover)

viability [%]

90,0 80,0

***

70,0 60,0 50,0 40,0 + cover

- cover

- cover

vehicle RT

vehicle RT

HyaCare Filler CL

*** p
View more...

Comments

Copyright � 2017 NANOPDF Inc.
SUPPORT NANOPDF