ISPHC-PresentationJean-GillesQuinnCamilleri

A cost-effectiveness evaluation of preventive interventions for HIV-TB in Sub-Saharan Africa (Tanzania): Relevance for neurological infections Lucie Jean-Gilles Casey Quinn Corinne Camilleri-Ferrante

Outline     

Background on HIV-Tuberculosis (TB) in SubSaharan Africa and neurological implications Prevention & treatments for HIV-TB Cost-effectiveness study for HIV-TB in Tanzania Implication of results and relevance to neuro-TB Conclusion and future directions

Background 

Burden of TB closely linked to HIV epidemic in SSA (80% of global co-infection cases) HIV increases risk for Mycobacterium tuberculosis infection and for latent TB progression into active disease (30-50 fold higher)

Microscopic view of T. Bacilli

Estimated global incidence of TB (2007)

http://www.who.int/tb/publications/global_report/2009/pdf/chapter1.pdf

Estimated global distribution of HIV prevalence in new TB cases (2007)

http://www.who.int/tb/publications/global_report/2009/pdf/chapter1.pdf

Background 

HIV-infected TB (prevalence 30-75% of ~7% Tanzania HIV prevalence) = high annual death incidence (↑ death risk