N0 - Springer Static Content Server

Supplementary Table 1: Selected candidate genes for targeted resequencing based on our previous linkage and association results in the MSTF AA and EA samples Gene Name

Gene Symbol

Chromosome

Reference

Ankyrin repeat and kinase domain containing 1

ANKK1

11

[1]

Beta-arestin 1

ARRB1

11

[2]

Beta-arrestin 2

ARRB2

17

[2]

Brain-derived neurotrophic factor

BDNF

11

[3]

Cadherin 13

CDH13

16

Catechol-O-methyltransferase

COMT

22

[4]

Choline acetyltransferase

CHAT

10q11

[5]

DOPA decarboxylase

DDC

7

[6]

Dopamine beta-monooxygenase

DBH

9q34

[7]

Dopamine receptor 1

DRD1

5

[8]

Dopamine receptor 2

DRD2

11

[1]

Dopamine receptor 3

DRD3

3

[9]

Dynamin 1

DNM1

9

[10]

GABA-B receptor subunit 2

GABBR2

9

[11]

Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

GRIN3A

9

[12]

Neurexin 1

NRXN1

2

[13]

Neurexin 2

NRXN2

11q13

Neurexin 3

NRXN3

14q31

Neurotrophic tyrosine kinase receptor type 2

NTRK2

9

Nicotinic receptor, alpha 1 subunit

CHRNA1

2

Nicotinic receptor, alpha 10 subunit

CHRNA10

11p15

Nicotinic receptor, alpha 2 subunit

CHRNA2

8

Nicotinic receptor, alpha 3 subunit

CHRNA3

15

[15]

Nicotinic receptor, alpha 4 subunit

CHRNA4

20

[16]

Nicotinic receptor, alpha 5 subunit

CHRNA5

15

[15]

Nicotinic receptor, alpha 6 subunit

CHRNA6

8

Nicotinic receptor, alpha 7 subunit

CHRNA7

15

Nicotinic receptor, alpha 9 subunit

CHRNA9

4p14

Nicotinic receptor, beta 1 subunit

CHRNB1

17p12

[14]

Nicotinic receptor, beta 2 subunit

CHRNB2

1q21

[16]

Nicotinic receptor, beta 3 subunit

CHRNB3

8p11

[17]

Nicotinic receptor, beta 4 subunit

CHRNB4

15q24

[15]

Taste receptor, type 2, member 38

TAS2R38

7

[18]

References: 1 Huang, W, Payne, TJ, Ma, JZ, Beuten, J, Dupont, RT, Inohara, N and Li, MD (2009) Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Neuropsychopharmacology, 34: 319-330. 2 Sun, D, Ma, JZ, Payne, TJ and Li, MD (2007) beta-Arrestins 1 and 2 are associated with nicotine dependence in European American smokers. Mol Psychiatry. 3 Beuten, J, Ma, JZ, Payne, TJ, Dupont, RT, Quezada, P, Huang, W, Crews, KM and Li, MD (2005) Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. Am J Med Genet B Neuropsychiatr Genet, 139: 73-80. 4 Beuten, J, Payne, TJ, Ma, JZ and Li, MD (2006) Significant association of catechol-Omethyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. Neuropsychopharmacology, 31: 675-684. 5 Wei, J, Ma, JZ, Payne, TJ, Cui, W, Ray, R, Mitra, N, Lerman, C and Li, MD (2010) Replication and extension of association of choline acetyltransferase with nicotine dependence in European and African American smokers. Human genetics, 127: 691-698. 6 Ma, JZ, Beuten, J, Payne, TJ, Dupont, RT, Elston, RC and Li, MD (2005) Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Human molecular genetics, 14: 1691-1698. 7 Thorgeirsson, TE, Gudbjartsson, DF, Surakka, I, Vink, JM, Amin, N, Geller, F, Sulem, P, Rafnar, T, Esko, T, Walter, S et al. (2010) Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature genetics, 42: 448-453. 8 Huang, W, Ma, JZ, Payne, TJ, Beuten, J, Dupont, RT and Li, MD (2008) Significant association of DRD1 with nicotine dependence. Human genetics, 123: 133-140. 9 Huang, W, Payne, TJ, Ma, JZ and Li, MD (2008) A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers. Am J Med Genet B Neuropsychiatr Genet, 147B: 1109-1115. 10 Xu, Q, Huang, W, Payne, TJ, Ma, JZ and Li, MD (2009) Detection of genetic association and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and African Americans. Neuropsychopharmacology, 34: 1351-1359. 11 Beuten, J, Ma, JZ, Payne, TJ, Dupont, RT, Crews, KM, Somes, G, Williams, NJ, Elston, RC and Li, MD (2005) Single- and Multilocus Allelic Variants within the GABAB Receptor Subunit 2 (GABAB2) Gene Are Significantly Associated with Nicotine Dependence. Am. J. Hum. Genet., 76: 859-864.

12 Ma, JZ, Payne, TJ and Li, MD (2010) Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers. Human genetics, 127: 503-512. 13 Nussbaum, J, Xu, Q, Payne, TJ, Ma, JZ, Huang, W, Gelernter, J and Li, MD (2008) Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in Europeanand African-American smokers. Human molecular genetics, 17: 1569-1577. 14 Beuten, J, Ma, JZ, Payne, TJ, Dupont, RT, Lou, XY, Crews, KM, Elston, RC and Li, MD (2007) Association of Specific Haplotypes of Neurotrophic Tyrosine Kinase Receptor 2 Gene (NTRK2) with Vulnerability to Nicotine Dependence in African-Americans and EuropeanAmericans. Biological psychiatry, 61: 48-55. 15 Li, MD, Xu, Q, Lou, XY, Payne, TJ, Niu, T and Ma, JZ (2010) Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. Am J Med Genet B Neuropsychiatr Genet, 153B: 745-756. 16 Li, MD, Beuten, J, Ma, JZ, Payne, TJ, Lou, XY, Garcia, V, Duenes, AS, Crews, KM and Elston, RC (2005) Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Human molecular genetics, 14: 1211-1219. 17 Cui, WY, Wang, S, Yang, J, Yi, SG, Yoon, D, Kim, YJ, Payne, TJ, Ma, JZ, Park, T and Li, MD (2013) Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations. Molecular psychiatry. 18 Mangold, JE, Payne, TJ, Ma, JZ, Chen, G and Li, MD (2008) Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. J Med Genet, 45: 578-582.