Slide competition - Scandinavian Society of Immunology

January 29, 2018 | Author: Anonymous | Category: Science, Health Science, Immunology
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Examples of cell surface molecules expressed by T cells CD4 CD3 TCR chemokine

Cytokine receptor

Helper Promote protective immunity against intracellular (Th1) or extracelullar(Th2, Th9, Th17) pathogens. Important in autoimmune, allergy and inflammatory diseases. BTLA CD3 TCR

TGFβR

CD8 CD3

TCR

SLAMF1

SLAMF6

CD3 NK1.1

TCR

γδ

Cytotoxic

NKT

Kill infected and transformed cells.

Modulate several immune responses, including cancer, autoimmunity, allergy, infection and graft- versushost disease.

Protect the host from viral infections and cancer.

γδ TCR

IFNγ- and IL-17A-producing cells. Posses a distint T cell receptor. composed of two glycoprotein chains called γ (gamma) chain and δ (delta) chain

CD44 CD8

CD3

CD3 TCR

B220

CD3

TCR

TCR CCR7

IL-7R

TIM3

CD8αα

Memory

Exhausted

Functionally inactive.

Intraepithelial lymphocytes are found in the gut.

Found in peripheral tissues (Effector memory T cell) or lymphoid organs (Central memory T cell).

Generated in chronic antigen- mediated TCR stimulation.

Generated after TCR activation in the absence other costimulatory signals.

LAG3

CD8αα

Anergic Important in avoiding autoimmune responses.

1B11

Play a role in in Immunity and autoimmunity thru the release of proinflammatory regulatory cytokines

Provide protection upon antigen challenge through rapidly proliferation and differentiation.

Express inhibitory receptors and lack effector cytokine production; not effective in antiviral immune responses.

José Pedro Lopes

Treg population

CD4

TCR

CD25

TR1 cell

Natural TReg cell

Inducible TReg cell

Surface phenotype αβ TCR, CD3, CD4

Surface phenotype αβ TCR, CD3, CD4, CD25, CTLA4, GITR

Surface phenotype αβ TCR, CD3, CD4, CD25, CTLA4, GITR

Effector molecules IL-10

Effector molecules IL-10, TGFβ, IL-35

Effector molecules IL-10, TGFβ

Function Derived from naïve T cells by immunosuppressive drugs or TGF-β and IL-27.

Function Immunosuppression and tolerance through contact-dependent and independent mechanisms.

Function Mediate immunosuppression and tolerance by contact-dependent and independent mechanisms

Originate in the thymus.

Generated from naïve T cells in the periphery.

CD3

CTLA4 GITR

Mediate immunosuppression and tolerance responses. By suppression or down regulation of induction and proliferation of effector T cells

José Pedro Lopes

Differentiation of Naïve CD4+ T Cells into TReg Bone marrow

CD4+CD8-

Thymus

FoxP3

CD25+

Natural FoxP3 TReg

CD25-

Induced FoxP3 TReg

Il-2, RA, TGF-β

Naïve T-cell

Teffector

José Pedro Lopes

Modulation of T cell response by TREG upon Infection PRR MHC CLASS II TCR

DC

CD80/ CD86 CD28

Naïve T-cell



Naïve T-cell differentiate into either CD4+ or CD8+ effector T-cells

Th1

TReg help to control Th1-type excessive response e.g infection triggered inflammation

Th2

TReg help to control Th2-type excessive response e.g pathogen triggered allergic reaction

pathogen

CD8+ Tcell TReg help to control CD8+ excessive killing host cells

TReg

Th17

Neutrophil

TReg help to control Th17-type excessive response e.g autoimmunity

José Pedro Lopes

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