Hello , Everyone !
Medical Immunology
Li Yi
医学免疫学
(李一)
Professor, Director of Ph D 教授、博士生导师 Department of Immunology 免疫学教研室
[email protected]
Today Study of immunology**
Overview of immunology***
Study of immunology** （一） 免疫学基本理论部分：20学时。
语言：以英文授课为主、中文总结为辅。 教材：采用国外英文教材为主、中文教材为辅。 授课方式:自讲与讲授两种相结合； 考试方式：50 分（闭卷考试）。 笔试（或口试）中英文必答、中文必答和中英文选答相结合。 （二） 免疫学研究进展部分： 20学时。 语言：以中文授课为主。 授课方式：“以研究专题为中心” 。 考试方式：50 分（开卷考试）。撰写综述。
教学模式确立
双语教学
保留性双语教学 (maintenance bilingual education) 沉浸式双语教学 (immersion program)
过渡式双语教学 (transitional bilingual education)
Approach to study of immunology
I. Study by yourself (Homework) II. Presentation in class III. Summary
Groups I.
9 study groups are needed (4-5 persons/group).
II. Study with your group partners (Homework). III. Talk by one member of your group in class. IV.
Summary by teacher.
免疫学基本理论部分： -- 50’
Presentation: 5’ Test:
45’
Presentation Evaluation Criteria 1. Presented or explained content clearly.
10
2. Emphasized important points.
10
3. Summarized or reviewed major points.
10
4. Used graphics or visual aids or other enhancements to support presentation.
10
5. Used appropriate voice volume and inflection. 10
IMMUNOLOGY ???
Let’s start with
questions
Question-1 Our environment contains a great variety of infectious microbes, why could we keep healthy?
Question-2
What should we do before transplanting blood ---Transfusion ?
Questions - 3 1.
Why do we need to do gene matching before transplantation ?
2.
Why is it very difficult to find perfect donor for recipient in transplantation ?
Question-4
Do you have any experience
about allergy?
What is the allergy?
Question-5
1. What is vaccine ? 2. How do vaccines work?
Questions？
Immunology
Answer！
Immunology Functions of IS
Immune System Pathology of IS
Applications
Overview of Immunology Components of IS Organs and tissues
Functions of IS Antigen (Ag)
Pathology of IR Hypersensitivity
Applications
Prevention
Autoimmune disease Cells
Immune Responses
Immunodeficiency Tumor
Molecules
Control mechanisms Transplantation rejection
* IS: Immune system IR: Immune response
Diagnosis Therapy
Functions of Immune System • Immunological defense • Immunological homeostasis
• Immunological surveillance
Functions of Immune System -1
• Immunological defense: The immune system protects us from
attack by microbes and worms.
Functions of Immune System -2
Immunological homeostasis : The immune system could eliminate the inflammatory or died self-cells.
Functions of Immune System -3
Immunological surveillance: The immune system could destroy the tumor cells and protects us from clinical tumor formation. Tumor cell
Tumor Tumor Tumor cell cell cell Tumor Tumor Tumor cell cell cell
Overview of Immunology Components of IS Organs and tissues
Functions of IS Antigen (Ag)
Pathology of IR Hypersensitivity
Applications
Prevention
Autoimmune disease Cells
Immune Responses
Immunodeficiency Tumor
Molecules
Control mechanisms Transplantation rejection
* IS: Immune system IR: Immune response
Diagnosis Therapy
Immune Responses
Immunologic defense Immunologic homeostasis Immunologic surveillance
Organs and tissues
Ag
IR
Cells Molecules
Hypersensitivity Immunodeficiency Autoimmune diseases Tumor Transplantation rejection
Components of immune system
Organs and tissues Cells Molecules
Components of IS -1
Organs and Tissues of Immune System — Primary lymphoid organs • Bone Marrow • Thymus
— Secondary lymphoid organs • Lymph nodes • Spleen
• Mucosa-associated lymphoid tissues (MALT)
Components of IS -2
Cells of Immune System —
—
—
Mononuclear phagocyte system
Granulocytes
Lymphocytes
Neutrophils Basophils Eosinophils T lymphocyte B lymphocyte NK (Natural killer cells)
Monocyte Macrophage Dendritic Cells
Classes of T cells TH: T help cells TH1 TH2
TC: T cytotoxic cells, CTL
Cells of Immune System Phagocytes: Cells of mononuclear phagocyte system Neutrophils (Polymorphonuclear neutrophils, PMN)
Auxiliary cells Basophiles (mast cells)
Cytotoxic cells Tc (CTLs) NK cells Eosinophils
Components of IS -3
Molecules of Immune System — Antibody (Ab) — Complement (C) — Cytokines (CK)
— Major Histocompatibility Complex (MHC)
Overview of Immunology Components of IS Organs and tissues
Functions of IS Antigen (Ag)
Pathology of IR Hypersensitivity
Applications
Prevention
Autoimmune disease Cells
Immune Responses
Immunodeficiency Tumor
Molecules
Control mechanisms Transplantation rejection
* IS: Immune system IR: Immune response
Diagnosis Therapy
Functions of Immune System Antigen (Ag) Immune Responses (IR) Control mechanisms See:
Immune Response (IR) Target cells
MHC CK
Th1
CKs
Tc NK
Ag
DCs MHC CK
Th2
CKs
Ab
B PMN
Complement
Types of Immune Response Innate immunity (Natural immunity)
Adaptive immunity (Acquired immunity)
Innate and Adaptive Immunity Innate immunity
Adaptive immunity
Cells
Mq/DCs Granulocytes NK cells
T and B cells
Molecules
Cytokines Complement
Antibodies
Characteristics
Responds rapidly No specificity No memory
Slow to start Highly specificity Memory
Overview of Immunology Components of IS
Functions of IS
Organs and tissues Cells
Antigen (Ag)
Pathology of IR
Hypersensitivity
Autoimmune
Molecules
－ Antibodies － Complement － Cytokines
disease
Immune Responses
Control mechanisms
－ MHC
* IS: Immune system IR: Immune response
Immunodeficiency
Tumor
Transplantation rejection
Applications
Prevention
Diagnosis Therapy
HYPERSENSITIVITY The immune system “overreacts ” to antigen function disorder or tissue damage
Types of hypersensitivity Type I:
Allergy or immediate
Type II:
Cytotoxic
Type III:
Immune complex
Type IV:
Cell mediated or delayed
Different ??
Mechanisms !!
Autoimmune disease (AD) CKs T Self
Mq
B
Ab Complement
Self-Ag
Immune system
Immune response
Tissue Damage
Immune Response (IR) Target cells
MHC CK
Tumor cell
Th1
CKs
Tc NK
DCs MHC CK
Th2
CKs
Ab
B PMN
Complement
Tumor escape from surveillance
Immune system
Tumor cell
Tumor Tumor cell cell Tumor Tumor Tumor cell cell cell TumorTumor cell cell
Clinical tumor
Why???
Rejection mechanisms Immune System Grafts
Ag
Immune response
Recipient
Grafts rejection
Overview of Immunology Components of IS
Functions of IS
Organs and tissues Cells
Antigen (Ag)
Immune Responses
Prevention
Immunodeficiency
Diagnosis
Tumor
－ Complement － Cytokines
Hypersensitivity
Applications
Autoimmune disease
Molecules
－ Antibodies
Pathology of IR
Control mechanisms
－ MHC
* IS: Immune system IR: Immune response
Transplantation rejection
Therapy
Study of immunology** （一） 免疫学基本理论部分：20学时。
语言：以英文授课为主、中文总结为辅。 教材：采用国外英文教材为主、中文教材为辅。 授课方式:自讲与讲授两种相结合； 考试方式：50 分（闭卷考试）。 笔试（或口试）中英文必答、中文必答和中英文选答相结合。 （二） 免疫学研究进展部分： 20学时。 语言：以中文授课为主。 授课方式：“以研究专题为中心” 。 考试方式：50 分（开卷考试）。撰写综述。
免疫学基本理论部分：20学时 Components of IS Organs and tissues [1]
Functions of IS
Antigen (Ag) [7]
Cells [2] Molecules
Immune Responses [8]
－ Antibodies [3] － Complement [4] － Cytokines [5] － MHC [6]
* IS: Immune system IR: Immune response
Control mechanisms [9]
