Alfons Gierl Lehrstuhl für Genetik Emil-Ramann-Str. 8 WZW Technische Universität München
[email protected] 08161-715640
Chapter 1 Genetics?
Modern Genetik Analysis Griffiths et al Freemann Concepts of Genetics Klug et al. Pearson International Edition (2009) Molecular Biology of THE CELL Alberts et al Garland Science Biotechnology Applying the Genetic Revolution David P. Clark, Nanette J. Pazdernik Academic Press
http://www.wzw.tum.de/genetik/ Downloadbereich Username: genetics Password: GMendel
Genetics is the analysis of the basis of heredity
Mendel
Chromosomes
DNA
Genetic Dissection Biosynthetic pathway
Enzymes
A
B
C
Genes
A
B
C
Mutation
Gene
Function
Genome Projects Bacteria, Yeast, Drosophila, C. elegans, Human, Arabidopsis
DNA sequence (whole genome)
bioinformatics
gene function
Reverse Genetics
AGACTTTCCAA....
DNA sequence
(of gene in question)
gene knock out
gene function
Genetics is one basis for gene technology Transgenic animals, plants and microorganisms
Transgenic mouse
Wild type MET1 antisense
Genetic model systems Which features qualify an organism?
Genetic model systems
E. coli Yeast C.elegans Drosophila Zebra Fish Mouse Arabidopsis Maize
low costs many progeny many phenotypes compact genomes
