News in ageing research - Link-Age

News in ageing research Specialized journals: Experimental Gerontology Ageing Research Reviews Mechanisms of Ageing and Development Journal of Gerontology Biogerontology European journal of ageing International journal of ageing and later life The internet journal of geriatrics and gerontology Neurobiology of ageing Archives of gerontology and Geriatrics Psychology and Ageing July 2007- August 2007 Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice (abstract) H Fu, L Kang, J S Jennings, S S Moy, A Perez, J DiRosario, D M McCarty & J Muenzer Gene Ther 2007 14: 1065-1077 Dispatch : C. elegans Aging: Proteolysis Cuts Both Ways (abstract) Bruce Bowerman Current Biology, Vol 17, R514-R516 Body composition by the four-compartment model: validity of the BOD POD for assessing body fat in mexican elderly (abstract) H Alemán-Mateo, R H Huerta, J Esparza-Romero, R O Méndez, R Urquidez & M E Valencia Eur J Clin Nutr 2007 61: 830-836 Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity (abstract) M C Polidori, E Mariani, G Baggio, L Deiana, C Carru, G M Pes, R Cecchetti, C Franceschi, U Senin & P Mecocci Eur J Clin Nutr 2007 61: 922-924 The human we rner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase Neil1 (abstract) Aditi Das, Istvan Boldogh, Jae Wan Lee, Jeanine A. Harrigan, Muralidhar L. Hegde, Jason Piotrowski, Nadja de Souza-Pinto, William Ramos, Marc M. Greenberg, Tapas K. Hazra, Sankar Mitra, and Vilhelm A. Bohr J. Biol. Chem. published 3 July 2007 Randomised phase III trial of carboplatin plus etoposide vs split doses of cisplatin plus etoposide in elderly or poor-risk patients with extensive disease small-cell lung cancer: JCOG 9702 (abstract) H Okamoto, K Watanabe, H Kunikane, A Yokoyama, S Kudoh, T Asakawa, T Shibata, H Kunitoh, T Tamura & N Saijo on Behalf of the Japan Clinical Oncology Group (JCOG)-Lung Cancer Study Group British Journal of Cancer (2007) 97, 162-169 Chronic treatment with resveratrol induces redox stresssenescence in p53-positive cancer cells (abstract) Elke H. Heiss, Yvonne D.C. Schilder, and Verena M. Dirsch J. Biol. Chem. published 11 July 2007

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Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids (abstract) Maria Almeida, Li Han, Marta Martin-Millan, Lilian I. Plotkin, Scott A. Stewart, Paula K. Roberson, Stavroula Kousteni, Charles A. O'Brien, Teresita Bellido, A. Michael Parfitt, Robert S. Weinstein, Robert L. Jilka, and Stavros C. Manolagas J. Biol. Chem. published 10 July 2007 p53 Mediates Senescence-Like Arrest Induced by Chronic Replicational Stress (abstract) Andriy Marusyk, Linda J. Wheeler, Christopher K. Mathews, and James DeGregori Mol. Cell. Biol. 2007;27 5336-5351 Trends in oxidative aging theories (abstract) Florian L. Muller, Michael S. Lustgarten, Youngmok Jang, Arlan Richardson and Holly Van Remmen Free Radical Biology and Medicine Volume 43, Issue 4, Pages 477-503 Delayed ageing through damage protection by the Arf/p53 pathway (abstract) Ander Matheu, Antonio Maraver, Peter Klatt, Ignacio Flores, Isabel Garcia-Cao, Consuelo Borras, Juana M. Flores, Jose Viña, Maria A. Blasco & Manuel Serrano Nature 448, 375-379 Parametric and Regional Maps of Free Serotonin 5HT1A Receptor Sites in Human Brain as Function of Age in Healthy Humans (abstract) Mette Møller, Steen Jakobsen & Albert Gjedde Neuropsychopharmacology 2007 32: 1707-1714 Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells (abstract) X. Ye, B. Zerlanko, A. Kennedy, G. Banumathy, R. Zhang, and P.D. Adams Molecular Cell, Vol 27, 183-196 Myostatin Blockade: A New Way to Enhance Skeletal Muscle Repair in Old Age? (abstract) Zipora Yablonka-Reuveni Mol Ther 2007 15: 1407-1409 Antagonism of Myostatin Enhances Muscle Regeneration During Sarcopenia (abstract) Victoria Siriett, Mônica Senna Salerno, Carole Berry, Gina Nicholas, Rob Bower, Ravi Kambadur & Mridula Sharma Mol Ther 2007 15: 1463-1470 Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis (abstract) Akiko Taguchi, Lynn M. Wartschow, Morris F. White Science 20: Vol. 317. no. 5836, pp. 369 - 372 Research Highlight: Neurodegenerative diseases: Age concerns (abstract) Katherine Whalley Nature Reviews Neuroscience 8, 572-573 Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age (abstract) Alex Soltermann, Stephan Koetzer, Franz Eigenmann & Paul Komminoth Mod Pathol 2007 20: 878-883 FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization (abstract)

Christian Hafner, Arndt Hartmann, Johanna M M van Oers, Robert Stoehr, Ellen C Zwarthoff, Ferdinand Hofstaedter, Michael Landthaler & Thomas Vogt Mod Pathol 2007 20: 895-903 Molecular chaperones regulate p53 and suppress senescence programs (abstract) Michael Sherman, Vladimir Gabai, Cornelia O’Callaghan and Julia Yaglom FEBS Letters Volume 581, Issue 19, Pages 3711-3715 Cellular Senescence in Cancer and Aging (abstract) Manuel Collado, Maria A. Blasco, and Manuel Serrano Cell, Vol 130, 223-233 Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress (abstract) L. Yan, D.E. Vatner, J.P. O'Connor, A. Ivessa, H. Ge, W. Chen, S. Hirotani, Y. Ishikawa, J. Sadoshima, and S.F. Vatner Cell, Vol 130, 247-258, 27 July 2007 Mitochondrial Fission and Fusion Mediators, hFis1 and OPA1, Modulate Cellular Senescence (abstract) Seungmin Lee, Seon-Yong Jeong, Won-Chung Lim, Sujeong Kim, Yong-Yea Park, Xuejun Sun, Richard J. Youle, and Hyeseong Cho J. Biol. Chem. 2007;282 22977-22983 itochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia (abstract) Eric L. Bell, Tatyana A. Klimova, James Eisenbart, Paul T. Schumacker, and Navdeep S. Chandel Mol. Cell. Biol. 2007;27 5737-5745 Normal or stress-induced fibroblast senescence involves COX-2 activity (abstract) Stéphanie Zdanov, David Bernard, Florence Debacq-Chainiaux, Sébastien Martien, Karo Gosselin, Chantal Vercamer, Fazia Chelli, Olivier Toussaint and Corinne Abbadie Experimental Cell Research Volume 313, Issue 14, Pages 3046-3056 Anti-angiogenic therapy of exudative age-related macular degeneration: current progress and emerging concepts (abstract) Agnès Noël, Maud Jost, Vincent Lambert, Julie Lecomte and Jean-Marie Rakic Trends in Molecular Medicine Volume 13, Issue 8, Pages 345-352 Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity (abstract) Chaehwa Park, Inkyoung Lee, Jun Ho Jang and Won Ki Kang FEBS Letters Volume 581, Issue 20, Pages 3800-3804 Vimentin Is the Specific Target in Skin Glycation: STRUCTURAL PREREQUISITES, FUNCTIONAL CONSEQUENCES, AND ROLE IN SKIN AGING (abstract) Thomas Kueper, Tilman Grune, Stefanie Prahl, Holger Lenz, Vivienne Welge, Tanja Biernoth, Yvonne Vogt, Gesa-Meike Muhr, Astrid Gaemlich, Tobias Jung, Gerrit Boemke, Hans-Peter Elsässer, Klaus-Peter Wittern, Horst Wenck, Franz Stäb, and Thomas Blatt J. Biol. Chem. 2007;282 23427-23436 Differential Association of Hemoglobin with Proinflammatory High Density Lipoproteins in Atherogenic/Hyperlipidemic Mice: A NOVEL BIOMARKER OF ATHEROSCLEROSIS (abstract) Junji Watanabe, Katherine J. Chou, James C. Liao, Yunan Miao, Hsiang-Hui Meng, Helen Ge, Victor Grijalva, Susan Hama, Kathy Kozak, Georgette Buga, Julian P. Whitelegge,

Terry D. Lee, Robin Farias-Eisner, Mohamad Navab, Alan M. Fogelman, and Srinivasa T. Reddy J. Biol. Chem. 2007;282 23698-23707 Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury (abstract) Patrick C H Hsieh, Vincent F M Segers, Michael E Davis, Catherine MacGillivray, Joseph Gannon, Jeffery D Molkentin, Jeffrey Robbins & Richard T Lee Nature Medicine 13, 970 - 974 Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging (abstract) Hongjun Liu, Maria M Fergusson, Rogerio M. Castilho, Jie Liu, Liu Cao, Jichun Chen, Daniela Malide, Ilsa I. Rovira, Daniel Schimel, Calvin J. Kuo, J. Silvio Gutkind, Paul M. Hwang, Toren Finkel Science 10 Vol. 317. no. 5839, pp. 803 - 806 Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis (abstract) Andrew S. Brack, Michael J. Conboy, Sudeep Roy, Mark Lee, Calvin J. Kuo, Charles Keller, Thomas A. Rando Science 10 Vol. 317. no. 5839, pp. 807 - 810 Sirtuins: critical regulators at the crossroads between cancer and aging (abstract) L R Saunders & E Verdin Oncogene 2007 26: 5489-5504 Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells (abstract) Petra Stöckl, Christina Zankl, Eveline Hütter, Hermann Unterluggauer, Peter Laun, Gino Heeren, Edith Bogengruber, Dietmar Herndler-Brandstetter, Michael Breitenbach and Pidder Jansen-Dürr Free Radical Biology and Medicine Volume 43, Issue 6 Pages 947-958 Age, sex and the risk of grade-specific second primary colorectal cancer: Evidence for the protective effect of female hormone (abstract) Wenbin Liang European Journal of Cancer Volume 43, Issue 12, Pages 1856-1861 Translational Research in Late-Life Mood Disorders: Implications for Future Intervention and Prevention Research (abstract) Gwenn S Smith, Faith M Gunning-Dixon, Francis E Lotrich, Warren D Taylor & Jovier D Evans Neuropsychopharmacology 2007 32: 1857-1875 Defining Hair Follicles in the Age of Stem Cell Bioengineering (abstract) Cheng-Ming Chuong, George Cotsarelis & Kurt Stenn J Invest Dermatol 2007 127: 2098-2100 The common biology of cancer and ageing (abstract) Toren Finkel, Manuel Serrano and Maria A. Blasco Nature 448, 767-774 Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age (abstract) Alex Soltermann, Stephan Koetzer, Franz Eigenmann & Paul Komminoth Mod Pathol 2007 20: 878-883

FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization (abstract) Christian Hafner, Arndt Hartmann, Johanna M M van Oers, Robert Stoehr, Ellen C Zwarthoff, Ferdinand Hofstaedter, Michael Landthaler & Thomas Vogt Mod Pathol 2007 20: 895-903 Blood and marrow transplantation in elderly acute myeloid leukaemia patients – older certainly is not better (abstract) T L Kiss, W Sabry, H M Lazarus & J H Lipton Bone Marrow Transplant 2007 40: 405-416 Economics: Age, health and wealth (online) Frances Cairncross News and Views: Nature 448, 875-876 Transgenerational response to nutrition, early life circumstances and longevity (abstract) Gunnar Kaati, Lars Olov Bygren, Marcus Pembrey & Michael Sjöström Eur J Hum Genet 2007 15: 784-790 Mutation analysis of candidate genes within the 2q33.3 linkage area for familial earlyonset generalised osteoarthritis (abstract) Josine L Min, Ingrid Meulenbelt, Margreet Kloppenburg, Cornelia M van Duijn & P Eline Slagboom Eur J Hum Genet 2007 15: 791-799 Busulphan is safe and efficient treatment in elderly patients thrombocythemia (abstract) L Shvidel, E Sigler, M Haran, A Klepfish, A Duek, A Berrebi & M Shtalrid Leukemia 2007 21: 2071-2072

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Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells (abstract) Kaori Igarashi, Ippei Sakimoto, Keiko Kataoka, Keisuke Ohta and Masahiko Miura Experimental Cell Research Volume 313, Issue 15, Pages 3326-3336 Research Highlight : Ageing: Getting old and cancer: hand-in-hand? (abstract) Gemma Alderton Nature Reviews Cancer 7, 641 Nature Reviews Molecular Cell Biology presents a special Focus that highlights the latest advances in our understanding of ageing at the molecular and cellular level, and how this translates to organismal ageing. In addition, experts Lenny Guarente, Cynthia Kenyon and David Sinclair discuss the promise and the challenges of this fast-moving field in the accompanying Podcast. To access the Focus content www.nature.com/nrm/focus/ageing

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Evidence for the association of the S100bold italic beta gene with low cognitive performance and dementia in the elderly (abstract) J-C Lambert, S Ferreira, J Gussekloo, L Christiansen, G Brysbaert, E Slagboom, D Cottel, T Petit, J-J Hauw, S T DeKosky, F Richard, C Berr, C Lendon, M Ilyas Kamboh, D Mann, K Christensen, R Westendorp & P Amouyel Mol Psychiatry 2007 12: 870-880

Properties, regulation and in vivo functions of a novel protein kinase D: C. elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and lifespan (abstract) Hui Feng, Min Ren, Lu Chen, and Charles S. Rubin J. Biol. Chem. published 29 August 2007