NEWSLETTER - American Society for Cell Biology

ASCB

JANUARY

2009

NEWSLETTER VOLUME

Staying Motivated and Energized

32,

NUMBER

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Scientific Citizenship Urged at ASCB Annual Meeting

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Weaving through the 48th ASCB Annual Meeting was a common thread: the importance of scientific citizenship. With eloquence and passion, a variety of speakers emphasized the need for scientists— and scientists in training—to proselytize for basic science. Where to champion the message? In the halls of academe and the halls of power. In lecture halls, university-wide colloquiums, company boardrooms, and representatives’ offices. To students, administrators, elected officials, neighbors, family and friends, scientists have an obligation. Education begins in the classroom…but it doesn’t end there. We need to reach the public and our elected officials, urged Keynote speaker Francis Collins, former director of the National Human Genome Research Institute.

Institutional Responses to Dual-Career Families Page 7

Science vs. Disease in Tanzania

Scientific Citizenship, continued on page 4

Francis Collins

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Inside President’s Column

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WICB Column

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International Affairs

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Dear Labby

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InCytes from MBC

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Public Policy Briefing

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Half-Century Fund Donors

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Update Contact Info

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Biology Scholars Program

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Members in the News

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Member Gifts

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ELSO-EMBO Merger

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New ASCB Members

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ASCB Emeritus Members

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Grants & Opportunities

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Calendar

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Coverage of the 48th ASCB Annual Meeting will be featured in the February 2009 ASCB Newsletter.

Cossart Named 2009 ASCB Council Member The ASCB Council has approved Pascale Cossart of the Pasteur Institute to finish the remaining one-year term of Timothy Mitchison on the ASCB Council, for 2009. Mitchison is the 2009 ASCB President-Elect. n

Did You Know...? You have free access to ASCB’s quarterly online journal, an assessment-based publication for educators in the life sciences: CBE—Life Sciences Education (CBE-LSE). n CBE-LSE examines education approaches for teaching cell biology, developmental biology, neuroscience, genetics, bioinformatics, and more. n You can download CBE-LSE’s new poster, featuring five questions to stimulate classroom discussion. n View the pdf at www.cellbioed.org/pdf/cbe_ poster.pdf. n Obtain a free copy from the ASCB Online Store. Go to www.ascb.org and click on “Online Store.” n The Winter 2008 issue of CBE-LSE is online now. Check it out at www.lifescied.org/current. dtl. CBE-LSE is supported in part by the Howard Hughes Medical Institute. n n

The American Society for Cell Biology 8120 Woodmont Avenue, Suite 750 Bethesda, MD 20814-2762 Tel: (301) 347-9300 Fax: (301) 347-9310 [email protected], www.ascb.org Joan R. Goldberg Executive Director Officers Brigid Hogan President Timothy J. Mitchison President-Elect Bob Goldman Past President Thoru Pederson Treasurer Jean E. Schwarzbauer Secretary Council Pascale Cossart Susan K. Dutcher D. Scott Emr Joan R. Goldberg, ex officio Holly V. Goodson Kathleen J. Green Elizabeth Sztul Paul W. Sternberg Clare M. Waterman Fiona M. Watt Susan R. Wente Susan M. Wick Virginia A. Zakian The ASCB Newsletter is published twelve times per year by The American Society for Cell Biology. Joan R. Goldberg Editor W. Mark Leader Editor Elizabeth M. Rich Production Manager Kevin Wilson Public Policy Director Ed Newman Advertising Manager John Fleischman Science Writer Thea Clarke Editorial Manager

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ASCB Newsletter ISSN 1060-8982 Volume 32, Number 1 January 2009 © 2009 The American Society for Cell Biology Postmaster: Send change of address to

ASCB Newsletter The American Society for Cell Biology 8120 Woodmont Avenue, Suite 750 Bethesda, MD 20814-2762

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PRESIDENT’S Column New Year’s Resolutions It is a great honor and pleasure to greet you as the new President of your Society. I know that you expect a great deal from me. Past presidents have all served you with outstanding vision and dedication. They have tirelessly promoted the core missions of the ASCB, helped balance the needs of different constituents with the resources available, and found ways to grow the Society and increase its influence. In the year ahead I will try to live up to their examples. I also will have to take on another challenge—to try to help everyone, and particularly young members, maintain a sense of optimism and enthusiasm in the face of the huge economic setbacks the world is experiencing. These economic problems will likely last several years. They will affect us all, whether we Brigid Hogan are chairs trying to balance department budgets, investigators resubmitting National Institutes of Health (NIH) or other grants, postdoctoral fellows applying for jobs in an ever-tightening market, or teachers trying to support families on a low income. One of the greatest driving forces to keep us motivated in the face of these difficulties is a burning passion for science. The joy to be gained from scientific inquiry and discovery was in evidence throughout the 2008 Annual Meeting in San Francisco. It was just as forcefully conveyed by students and postdoctoral fellows at their posters as by winners of awards at their special lectures. So how can we maintain our enthusiasm for science, and stay innovative and creative when there is so much to discourage us? I would like to propose two scientific “New Year’s Resolutions” that may help us stay motivated and energized. These resolutions are, of course, in addition to the others that we have made, such as to exercise more, reduce our carbon footprint, and support our local communities!

Resolution 1: Think Outside the (Cell Biology) Box When faced with reduced funding or a decline in resources, it is easy to “hunker down” and

to concentrate more and more on a few ideas. You feel too pressed to learn about something new, or you tell your students to focus on one particular project. Of course, focus is a good thing—especially for students and postdocs! But there is a great deal to be gained from thinking outside the box and viewing issues from a different perspective. By taking time to learn about other people’s research, you may suddenly recognize an unexpected link between your problem and one that has just been solved. Or you may discover a new technique that could be applied to your own material. Alternatively, you may realize that your experimental approach could help solve a completely different question being studied by someone else. So I would like to encourage you all to take time to learn about a topic that is very different from your own. Go to a seminar by an outside speaker that you would normally pass over and, what’s more, take a student with you. Read a paper or commentary in a journal that you would otherwise ignore, and then discuss it with your colleagues afterwards. Another approach would be to follow a link in PubMed from a paper in your field and then see where it takes you. For members attending the ASCB Annual Meetings, the rich selection of talks and posters provides many opportunities for such lateral thinking. In addition, for the past two years the meeting has included “Working Groups.” At these sessions a few leaders in a field present different aspects of a problem and then open the session to discussion from the audience. Organizers choose topics to be either controversial or particularly amenable to new and collaborative approaches. These sessions have been very successful. There is no reason why a similar approach could not be tried in a much smaller venue, for example in a departmental or institutional retreat. One of the goals of these groups is to introduce the idea that lively discussion and arguments can be fun. Unfortunately, young scientists from some cultures or backgrounds ASCB NEWSLETTER JANUARY 2009

may not feel comfortable arguing with senior people or presenting alternative ideas in formal seminars. Informal “working groups” can help to overcome these reservations and introduce the idea that discussing science and challenging experts can be fun and very stimulating for everyone. Another way to think outside the box is to ask how your research might relate to complex biological questions such as organ development or repair after injury, or to a human disease. There have been some outstanding examples over the past few years of quite unexpected connections between cell biology, developmental biology, and disease processes. Two that come immediately to mind are the link between nuclear lamins and progeria, and between cilia and the multiple developmental defects seen in patients suffering from disorders such as BardetBiedl and Meckel-Gruber syndromes, known collectively as ciliopathies. (See the July and December 2008 ASCB Newsletter stories on this research for more information.) The ASCB is highlighting these examples in stories disseminated to community newspapers and to legislators and their staff to bring attention to the need for more NIH funding for basic research. (If you’d like to help disseminate such stories at your institution and to your elected officials, visit www.ascb.org/progeria and download and forward this example.) Sharing such stories with your colleagues can also help highlight how unexpected interconnections bring together scientists working in different fields, inspiring and invigorating their research.

Resolution 2: Communicate More about Our Research An excellent way to become re-energized and regain the child-like enthusiasm we once had is to explain to someone who works in another field, or who is not a scientist, why we find our work so interesting. This can be a real challenge, but the effort also has the potential to be very energizing. I find that people are usually fascinated to know about what cell biologists do, and they crave to learn more about the mysteries of life. There are many ways in which we can communicate our excitement about cells, and the ASCB is here to help. For example, at the ASCB Annual Meeting, sessions focused on talking about science to our neighbors and discussed outreach to legislators. In addition, a JANUARY 2009 ASCB NEWSLETTER

workshop showed how we can make or correct Wikipedia entries. (The February 2009 ASCB Newsletter will feature more information about these sessions.) Wikipedia is now widely used by young people to learn about science, but the information related to cell biology is often inadequate and out of date. Another example of how the ASCB promotes science communication in unconventional ways is the decision to place the winning Celldance contest videos, premiered at the ASCB Annual Meeting, on YouTube. There they have the potential to reach a huge audience, including people who might never open a newspaper or even watch TV. Indeed, we as scientists need to think much more about the changing face of journalism and take advantage of the new and alternative routes to communicate science to the public.One example of this was the video placed last year onYouTube by neurobiologists at the University of North Carolina, Chapel Hill. The video was made in response to the criticism by Alaska Governor Sarah Palin, then a vice presidential candidate, of federal funding for fruit fly research. Her comments implied that money spent on studies on flies could have “little or nothing” to do with human health problems such as autism. The video showed how basic research using Drosophila was illuminating the function of neurexins, proteins localized in neuronal synapses. Abnormalities in neurexins have been implicated in cognitive disorders in people, including autism. This video was an effective way for scientists to defend and explain their work to a much larger audience than they could otherwise reach without extensive resources. In addition, 2008 E.B. Wilson Medalist Martin Chalfie explained the importance of the research on http://airamerica.com. In future columns I hope to feature members of the ASCB on how they stay enthusiastic about science, and how they help communicate this to others. I will also showcase examples of how we as a Society can help scientists and scientists in training from disadvantaged communities, who are particularly vulnerable to economic downturns, to stay motivated about their work and build their careers. Working together, and keeping our resolutions, we can make 2009 a fantastic year for everyone in the ASCB. n Comments are welcome and should be sent to [email protected].

By taking time to learn about other people’s research, you may suddenly recognize an unexpected link between your problem and one that has just been solved. Or you may discover a new technique that could be applied to your own material.

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Burns noted. Often, the courses are, in effect, “ASCB does a great job of staying interactive “terminal” science classes, as Jay Labov of the with policy,” Collins told ASCB Annual National Academy of Sciences has observed. Meeting attendees at the conclusion of his talk. It doesn’t have to be that way. So Oates That’s critical because “good science requires posed the question: Why did she and others good science policy,” he added. Collins advised become scientists? “It wasn’t because we liked persistent public and policymaker outreach. to memorize vocabulary words or definitions “You’ve got to keep at it,” he emphasized. or run experiments with known results, U.S. attendees were particularly appreciative predictable reactions, and all we had to do is of Collins’ remarks that in the Obama follow instructions someone else provided,” she administration “we’ll have an administration answered. “We had questions about things that that’s actually interested in science.” Collins mattered to us.” serves on an Obama transition team. He called In recognition that students want to attention to the Obama-Biden “apply what they know,” “use platform’s call for increased knowledge,” “know why they investment in science. “I think should learn more,” and “be you’ll see that science will be let into our intellectual world,” Teaching science, at the table when important as Oates put it, she and Burns decisions are made. So I developed SENCER courses. like teaching encourage you to take action They embraced the following democracy, involves when exhorted to do so,” he lofty, intertwined goals: concluded. n Create scientific citizens teaching important n Teach science that’s relevant concepts... to contemporary problems Promoting Relevance like scientific n Promote social justice “Democratic process is akin n Foster civil engagement in many respects to scientific citizenship. Targeting an area of practice,” according to 2008 interest—such as cancer or ASCB Bruce Alberts Award for climate change—offers a lens Excellence in Science Education for viewing how science works. recipient Wm. David Burns. Problems may lie at the “edges of academic It’s “a process for dealing with problems which disciplines,” Burns noted because, as Woody acknowledges uncertainty, sees its results as McKenzie said, “‘life is not parsed like the provisional, subjects its practices to a degree undergraduate curriculum.’” of public inspection, is socially mediated, and Not surprisingly, many courses for science involves hard work and cooperation.” majors have now been “SENCERized.” Burns Teaching science, like teaching democracy, noted that SENCER courses began with HIV involves teaching important concepts…like scientific citizenship. And when science is tied to and a focus on cell biology; they have expanded real issues, learning is improved, Burns observed. to embrace climate, nanotechnology, obesity, traffic, and more. There are 38 model courses, What do students learn in undergraduate and faculty design and teach new courses, apply classrooms about the importance and relevance of what scientists do and how to apply scientific new pedagogies, and employ new assessment concepts? In many classrooms, the answer is not techniques. Kelly Wentz-Hunter of Roosevelt much. Instead students are “sprayed with 10,000 University was recognized at the ASCB Annual Meeting for her course on cancer. More are sure definitions,” noted Burns. He is at the National to follow as assessment of SENCER courses Center for Science and Civic Engagement at Harrisburg University. He and fellow awardee Karen K. Oates developed a better way to teach science. Oates is currently affiliated with the Division of Undergraduate Education at the U.S. National Science Foundation. Interestingly, Burns and Oates didn’t initially focus their program, Science Education for New Civic Engagements and Responsibilities (SENCER), on scientific majors. Instead they targeted nonmajors enrolled in introductory science courses; such courses were “true bridges to nowhere,” as Left to right: Tim Stearns, Karen Oates, Wm. David Burns Scientific Citizenship, continued from page 1

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ASCB NEWSLETTER JANUARY 2009

Bob Goldman (center) with Roger Y. Tsien (left) and Martin Chalfie (right) as they display their 2008 ASCB E.B. Wilson Medals.

offers further evidence that Burns and Oates are on to something. For more information on SENCER courses, visit www.sencer.net.

Recognizing Basic Science Another ASCB Annual Meeting highlight was the presentation of the E.B. Wilson Medal to two of the 2008 Nobel Laureates in Chemistry, longtime ASCB members Martin Chalfie and Roger Y. Tsien. On the heels of their Nobel acceptance in Sweden, the Nobel Laureates arrived in San Francisco, jet-lagged but happy to be honored at the ASCB Annual Meeting. As then ASCB President Bob Goldman noted, the E.B. Wilson Medal selection was announced months before the Nobel. Chalfie noted his pleasure in receiving the award, “in addition to the obvious reasons for feeling so honored. First, this award is a prize for basic science. GFP was discovered by Osamu Shimomura in a quest to answer a fascinating question: How can some organisms produce light? And the tools that Roger Tsien and I have developed enable additional investigations in cell biology, developmental biology, neurobiology, in fact, throughout the life sciences.” At a time when a U.S. vice presidential candidate failed to recognize the connection between the study of nonhuman organisms and human disease, Chalfie’s words were particularly resonant: “I would also add that the study of C. [Caenorhabditis] elegans, a soil nematode, has also taught us so much about life. These days one hears much talk about how science should be directed more toward translational research, research that applies understanding gained in the laboratory to problems in human health. Although the application of knowledge to human health and well-being is obviously important, I feel that many statements urging a switch from basic to translational research are based on two false premises.” JANUARY 2009 ASCB NEWSLETTER

Chalfie continued, “The first is that scientists are either uncaring or ignorant of the implications of their research for human disease. I find this attitude ironic and false, since virtually every scientist I know thinks deeply about the meaning and implications of his or her research. Second, I feel that some people promoting translational research act as if we have already learned all that we need to know to cure human diseases.” As Chalfie added, this is far from the case: “We have so much more to learn. Not only what these proteins do, but also how they all interact together to sustain life and development. As many people have said, one needs to have material to translate to have translational research. And when we consider how few organisms scientists have studied, the mystery that surrounds us becomes even greater. What will be the Aequoria victoria and C. elegans of the future? Indeed, what will be the GFP of the future?” The past, present, and future of cell biology were showcased in San Francisco last month. So too was the need for advocacy by scientific citizens. If not us, then who? —Joan R. Goldberg

“We have so much to learn.... [O]ne needs to have material to translate to have translational research.”

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WOMEN in Cell Biology Women and Men Together in the Academy: Institutional Implications individuals can find the particular supports that As more women receive Ph.D.s and set out to matter to them. forge lives that include commitments to both career and family, universities must consider the implications of this shift for the resources and Expanding Support as Families supports they provide. In addition, more men Change want to add commitments to their families to Universities are strongly committed to their traditional commitments having productive faculty. To to their careers, and this has accomplish this, they provide similar implications. A recent [U]niversities must resources designed to help survey of Princeton University faculty be as accomplished as understand that faculty highlights the fact that possible in their research and they have always the dual-career family has teaching. Much of this support become the norm rather than has focused on the professional provided resources the exception: lives of faculty (e.g., laboratory and support for the n Eighty-two percent of space, equipment, etc.), but tenured women and 92% of personal lives of supports for family life have tenured men are married or traditionally been provided as faculty. The shift in a domestic partnership. well. For example, universities n Seventy percent of tenurein work/family life have for many years provided track women and 82% of health insurance, life insurance, configurations... tenure-track men are married housing, and tuition grant simply changes or in a domestic partnership. programs. This traditional n Of those who were married configuration of resources the range and or in a domestic partnership, served everyone well for many specifics of what 98% of tenured women and decades, but a different (and 75% of tenured men have must be provided. expanded) configuration is working spouses or domestic needed now that the prevailing partners. norm is no longer men who n Among younger faculty, 96% of tenure-track concentrate on their careers and women who women and 81% of tenure-track men have concentrate on their families. working spouses or domestic partners. I believe the prevalence of dual-career Graduate Students and Postdocs families means that universities must revise Have Families Too their thinking in three ways. First, universities Since many assistant professors are already must understand that they have always part of dual-career families, for many people provided resources and support for the the juggling that is an inevitable aspect of personal lives of faculty. The shift in work/ commitments to both career and family life family life configurations outlined above simply must have begun during the graduate student changes the range and specifics of what must or postdoc years. This suggests that universities be provided. Second, universities in recent need to consider the kinds of supports they years have focused their support efforts on the provide for graduate students and postdocs assistant professor years when the competition beyond the traditional supports that have been between work and family life seems most acute. provided for career formation. Now universities must also pay attention to The need may be quite urgent. At Princeton, graduate students and postdocs, in whose lives we find that the percentage of women among career and family formation are often taking the applicants for assistant professor positions place simultaneously. Third, as the family is substantially lower than the percentage of configurations of graduate students, postdocs, women receiving Ph.D.s. Similar data have been and faculty become more variable, the range reported at other research universities. There of programs provided must increase so that are many possible reasons for this consistent JANUARY 2009 ASCB NEWSLETTER

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It is important to remember that the early years of an academic career, which are full of uncertainty and which often require several household moves, are the years when the decision is made whether (or not) to proceed to a faculty career

disparity. One hypothesis is that many women, daunted by the prospect of dealing simultaneously with family demands and career demands in the intense setting of establishing a tenurable record at a research university, opt for other professional venues. Some support for this hypothesis can be found in an exceptionally interesting article in EMBO Reports that reported data from a survey of 1,300 intramural postdoctoral fellows at the National Institutes of Health.1 Two-thirds of the male survey respondents but only one-half of the female survey respondents said that they were considering a PI position, and the disparity between men and women was even greater among respondents who were married with children. The survey asked respondents to rank 15 factors that could influence their decision to pursue a position as a PI. Across the board, the largest differences between men and women occurred on items that related to children, spending time with children, and spending time with other family members. (It is important to note that there were no significant differences between men and women in how they rated factors such as competition, managerial duties, or the need to obtain tenure.) These data suggest that universities must find ways to help graduate students and postdocs, as well as faculty, balance the demands of professional and family life if they hope to take advantage of the full range of available scientific talent. It is important to remember that the early years of an academic career, which are full of uncertainty and which often require several household moves, are the years when the decision is made whether (or not) to proceed to a faculty career.

Want to Discuss Career and Life Issues Online? A moderated blog, established by the Women in Cell Biology (WICB) Committee offers you an opportunity to discuss career, family, and other “life” issues. You’ll find the blog at www.ascb.org. Click on “Committees,” “Women in Cell Biology,” “WICB Blog.” To join the conversation, simply click on “create an account” at the top right of the page. Then respond to an ongoing thread or start your own. If you have questions, feel free to contact moderator Deepti Pradhan ([email protected]). Looking forward to your participation! n 8

Meeting Varied Needs Families come in many different shapes and sizes, and indeed the configuration of individual families can change over time. Thus, the resources and supports that people need vary a lot. (This is of course also true for the professional resources and supports that people need— think, for example, of laboratory fittings versus library needs—but universities are accustomed to taking these differences into account.) Such varied needs suggest that universities should try to provide a panoply of policies and programs. At Princeton, where we have tried to do this, the programs include: n For each new child in the family, automatic one-year extensions of the pre-tenure period for assistant professors and one-semester extensions of support for graduate students n Grants for childcare when people are traveling to conferences and workshops n Subsidized back-up care when any member of the family is ill n Income-based grants to subsidize the cost of daily childcare To learn more about the programs for Princeton faculty visit www.princeton.edu/ dof/policies/family_friendly. To learn more about those for graduate students, visit http:// gradschool.princeton.edu/studentlife/childcare.

A Final Point Especially in the current economic climate, many university administrators feel that they cannot afford to provide all the personal and family supports for graduate students, postdocs, and faculty that are now needed. This is undoubtedly true. I would urge two things. First, it would be exceedingly helpful if every university would publicly acknowledge the importance of a range of policies and programs to support the new family configurations that impact the work of faculty, postdocs, and graduate students, and declare its intention to provide these supports when and if it can. Second, it would also be helpful if every university undertook to design and implement one or two low-cost policies or programs as a clear signal to its graduate students, postdocs, and faculty that it is determined to take advantage of all the available talent and to provide what is needed to do so. n —Joan S. Girgus, Princeton University

Reference Martinez ED, Botos J, Dohoney KM, Geiman TM, Kolla SS, Olivera A, Qiu Y, Rayasam GV, Stavreva DA, Cohen-Fix O. (2007). Falling off the academic bandwagon: Women are more likely to quit at the postdoc to principal investigator transition. EMBO Reports 8, 977–981.

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ASCB NEWSLETTER JANUARY 2009

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partnership like this.

INTERNATIONAL Affairs An allied Genome Science Center (GSC) at Sokoine University of Agriculture (focused on microarrays and bioinformatics studies of global infectious diseases) In 2007, the GSC, led by Professor Paul Gwakisa, fabricated the first DNA microarrays ever produced in East Africa. The GSC is now focusing on transcriptional studies of Plasmodium falciparum parasites that cause severe malaria.

Launching, Supporting MOMS

A key element of the MOMS Project has been an integrated program of graduate training for young African scientists interested in molecular and cell biology studies related to malaria pathogenesis and immunity. The training program provides long-term support to young Tanzanian scientists conducting their graduate thesis or postdoctoral fellowship research. This is supported in part by funds from the Fogarty International Center at NIH, and through the GCGH award administered by the Foundation for NIH. The training program also organizes annual regional workshops for short-term intensive training opportunities, with a distinct theme each year. The program’s primary focus is on malaria in pregnant women and young children. However, it trains in other diseases such as trypanosomiasis, which also afflict humans and animals in the East African region. In 2008, the program joined forces with the American Society for Cell Biology to focus its annual workshop on the theme “Cell Biology of Protozoan Pathogens.” Illustrious Society members, such as Dick McIntosh, Keith Gull, and David Roos, guided 24 young scientists from Uganda, Kenya, and Tanzania through an intensive foray into the basics of cell biology. Other faculty members led modules on immunology and vaccine development, parasite genomics and drug discovery, and functional genomics and bioinformatics. The workshop emphasized student participation through journal clubs, ethics discussions, group problemsolving exercises, hands-on laboratory sessions, and informal interactions. As a highlight of

Launched by T. K. Mutabingwa of the National Institute for Medical Research in Tanzania, and Michal Fried and Patrick Duffy of Seattle Biomedical Research Institute and University of Washington, the international partnership was Patrick Duffy initiated in 2002. The clinical research project known as the Mother-Offspring Malaria Studies (MOMS) Project began in a small, 600-square-foot laboratory. The lab was erected at the relatively isolated Muheza district hospital in northeastern Tanzania. Within this small footprint, MOMS Project scientists brought in everything they needed to perform detailed studies of parasites and immune cells. This included power generators, back-up water supplies, and a VSAT (very small aperture terminal) connection to the Internet. Initially supported by a grant from the U.S. National Institutes of Health (NIH), the scientists installed facilities for cell culture, parasite biology, and molecular biology, as well as a routine clinical laboratory to support the medical care provided to study participants. Since that small beginning, the MOMS Project has received major funding awards from the Grand Challenges in Global Health (GCGH) program, Bill & Melinda Gates Foundation, and NIH. Over the ensuing six years since its inception, MOMS has grown in to a regional center of excellence. It now includes: n The original clinical research laboratory in Muheza n A second clinical research laboratory at the Morogoro Regional Hospital (a six-hour drive from Muheza) JANUARY 2009 ASCB NEWSLETTER

n

nationa r e t

fai l Af rs

A horrifying statistic—malaria is said to kill an African child every 30 seconds. Many of these deaths occur in populations with little access to healthcare, and beyond the reach of research efforts that might find new solutions. Tanzanian and American scientists are working together to turn the tide against this deadly disease, by focusing on basic aspects of parasite biology and host-parasite interactions, and by training the next generation of scientists.

In

Science in Tanzania

Offering Training

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Research activities of all stripes have visibly increased in Tanzania over recent years.

the workshop, the students also worked in small groups under the mentorship of two to three faculty scientists to develop research proposals. Students then took proposals back to their research stations. Graduates of previous workshops have used these proposals to obtain competitive funding, to complete their theses, and to produce publications. Training is a fundamental element that defines the MOMS Project. It creates an atmosphere of mutual benefit, extends the scientific resources of the project, attracts the participation of additional partners, and develops the cadre of African researchers who can translate scientific advances into public health interventions in the future. Of note, a successful training program for molecular sciences and cell biology requires a sophisticated infrastructure that will attract and engage bright young minds. The MOMS Project infrastructure includes substantial laboratory capabilities at surprisingly remote locations. These include facilities as diverse as quantitative PCR, flow cytometry, malaria diagnostics, fluorescent microscopy, parasite culture, and microarray fabrication and analysis. Computer networks and Internet connections link the different laboratories in the MOMS network. They also provide the Web-based resources that

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are essential to the work of its young (and its middle-aged!) scientists.

Conducting Research The research undertaken by the scientists and students of the MOMS Project also reflects their diverse interests and tools. Tanzanian M.D.-Ph.D. student Edward Kabyemela recently published work showing that the fetal response to maternal malaria can influence fetal outcomes. In another study he showed that mothers with iron deficiency are protected from malaria for unknown reasons. University of Washington M.D.-Ph.D. student Atis Muehlenbachs found evidence of maternalfetal conflict in the VEGF-VEGFR pathway during placental malaria. Subsequently, she demonstrated that the fetal gene encoding VEGFR is a malaria resistance gene. This was the first example of a resistance gene against any infectious disease that functions in utero. Scientist Susan Francis used microarrays and other tools to show that the malaria parasites that infect pregnant women express a distinct subset of genes. The proteins encoded by these genes are now being assessed as potential vaccine candidates to protect pregnant women from malaria. Research activities of all stripes have visibly increased in Tanzania over recent years. The MOMS Project foresees a continuing role for itself as a partner and catalyst for studies of pregnancy and childhood malaria, emphasizing advanced technologies and molecular and cellular studies. Its success will ultimately be judged according to the degree to which its research findings and capabilities are disseminated throughout endemic areas. In the anonymous words of one MOMS Project workshop participant: “Thank you very much. Inviting participants who do not have access to such trainings is really a good investment. It helps not only the participant, but also the institution where we come from.” In the future, expect to see increasing productivity from East African scientists focused on cell and molecular biology, particularly where those studies are relevant to the devastating diseases that afflict their communities. n —Patrick Duffy, Seattle Biomedical Research Institute

For the latest Nuclear Signaling pathways, posters and conferences visit

www.abcam.com/nuclearsignal 12

ASCB NEWSLETTER JANUARY 2009

DEAR Labby Dear Labby, I am a professor at an East Coast university where we are revising our Ph.D. thesis guidelines. (The Dean asked me to undertake this process.) Now a key issue has arisen on which I need information: Namely, to what extent is it proper to allow students to insert text into their thesis identical to that in papers they have or are publishing during their graduate work? We presently take a very liberal stance on this, but some faculty members have questioned our position occasionally. In the course of seeking information from our counterparts at other institutions, and benchmarking our practices, it occurred to me—as an ASCB member—to seek Labby’s thoughts as well. —Thesisologist

Dear Thesisologist, We have come a long way from the time when the thesis was the only publication expected by the guild or needed by the student, from an era when the entire text was generated ab initio and expected to appear nowhere else. Policies today vary but, in general, it has become the custom to allow students to insert the text of a published, accepted, or submitted manuscript as a chapter of the Results section. Various issues loom however. In the simplest case, a student plays a major role in writing the paper and is the sole author other than the faculty member. (Note that we have also “progressed,” at least in certain quarters, past the time when the professor was not a coauthor; the late Hewson Swift was particularly generous in this regard). In such cases, it seems acceptable for the student to put the very same text into the thesis, in whatever transfer of sections the format requires (e.g., Materials and Methods to Materials and Methods, etc.), as long as this is acknowledged. Such an acknowledgment might read: “The following chapter is taken from the Results section of the paper by Smith and Jones, Mol. Biol. Cell 19: 5604–5618, 2008.” (Note the authors’ good taste in choosing a journal for publication.) After all, if in the published paper the student had written “Figure 4A shows the sucrose gradient profile of the complex,” it would seem silly to require this to be written in the thesis as: “The chromatin remodeling complex displayed a sedimentation coefficient of ~23S (Figure 4A),” since nothing is being taught to the student by this harassment. Moreover, the verbatim text is rendered legitimate by the acknowledgment of its source. However, it is a dicier matter when the student’s publication has been co-written with other authors, including the faculty adviser. If a co-author has written a paragraph (in any section), with no input into that paragraph by the student, then in Labby’s view, it should not be inserted into the thesis. The point being made can certainly be conveyed easily enough in a paragraph written de novo. From here, there is an ascending staircase of severity of misuse of text. On one “step” there could be for example a brilliant insight into the findings made solely by a co-author in the published article. In such a case, the thesis sentence would need to state: “Notwithstanding the aforementioned interpretations, we ultimately have concluded that the most plausible one is that developed by Ida Bean Feynman in our laboratory, as further developed in our recent publication Jones, Feynman, and Smith (2009).” One caution should be noted even in the acceptable case where a student uses verbatim text mentioned above. Labby knows of a recent case in which a faculty member plagiarized herself, i.e., used identical text (Introduction and Discussion) in multiple publications. The motive was not to deceive but resulted from sheer intellectual laziness (precipitating due wrath by the institution’s investigative committee). So if we allow our students to use verbatim text in their theses, we should mentor that this is actually a statutory exception to the standard doctrine about publications. Other publications will not be governed by this relaxed standard. n —Labby Correction: Labby’s reply in the December column contained two errors: “refracting” should have read “diffracting” and the name of the company’s hopeful cancer therapeutic protein should have read “curein.” Direct your questions to [email protected]. Authors of questions chosen for publication may indicate whether or not they wish to be identified. Submissions may be edited for space and style.

JANUARY 2009 ASCB NEWSLETTER

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By Michael F. Carey, University of California, Los Angeles; Craig L. Peterson, University of Massachusetts Medical School, Worcester; and Stephen T. Smale, University of California, Los Angeles

S

trategies for studying gene regulation mechanisms have changed dramatically over the past several years in light of the emergence of complete genome sequences for many organisms as well as the development of or improvements to technologies such as chromatin immunoprecipitation, RNA interference, microarrays, and proteomics. The first edition of the highly successful Transcriptional Regulation in Eukaryotes, written by Michael Carey and Stephen Smale at UCLA, provided a comprehensive source of strategic, conceptual, and technical information for investigating the complexities of gene regulation at the level of transcription. With the ever-increasing importance of genome data and the appearance of new and better techniques, the second edition of this book has added a third author, Craig Peterson at the University of Massachusetts Medical School. In addition to a new chapter on the in vitro analysis of chromatin templates for DNA-binding studies and transcription, this second edition has been extensively rewritten and updated to discuss new advances in the field and their impact on gene regulation mechanisms. The second edition retains the approach of the first in covering both the conceptual and practical aspects of how to study the regulation of a newly isolated gene and the biochemistry of a new transcription factor. Transcriptional Regulation in Eukaryotes serves as both a powerful textbook and manual for advanced instruction in molecular biology which • supplements clearly written text with extensive illustrations • puts methods in the context of underlying theory • gives expert recommendations on experimental strategies • encourages creativity in investigative design • explains protocols for essential techniques step by step, with extensive advice on troubleshooting • provides the latest methods in use in the field This important and unique book is essential reading for anyone pursuing the analysis of gene expression in model systems or disease states, providing underlying theory and perspective to the newcomer and the latest techniques to the expert. Published in December 2008, 620 pp., appendix, index Hardcover $240 Paperback $165

ISBN 978-087969777-8 ISBN 978-087969762-4

CONTENTS Preface Overview Abbreviations and Acronyms 1. A Primer on Transcriptional Regulation in Mammalian Cells 2. Initial Strategic Issues 3. Transcription Initiation Site Mapping 4. Functional Assays for Promoter Analysis 5. Identification and Analysis of Distant Control Regions

6. Identifying cis-Acting DNA Elements within a Control Region 7. Identification of DNA-Binding Proteins and Their Genes 8. Confirming the Functional Importance of a Protein–DNA Interaction 9. In Vivo Analysis of an Endogenous Control Region 10. Identifying and Characterizing Domains of Transcription Regulatory Factors

11. DNA Binding by Regulatory Transcription Factors 12. Transcription and Preinitiation Complex Assembly In Vitro 13. Studying Chromatin Dynamics In Vitro: Chromatin Assembly, Remodeling, and Transcription Appendix: Cautions Index

To order or request additional information, please visit our website or: Call: 1-800-843-4388 (Continental US and Canada) 516-422-4100 (All other locations) Fax: 516-422-4097 E-mail: [email protected] Write: Cold Spring Harbor Laboratory Press, 500 Sunnyside Blvd., Woodbury, NY 11797-2924

InCytes from MBC January, Vol. 20, Nos. 1 and 2 Sterols Are Mainly in the Cytoplasmic Leaflet of the Plasma Membrane and the Endocytic Recycling Compartment in CHO Cells Mousumi Mondal, Bruno Mesmin, Sushmita Mukherjee, and Frederick R. Maxfield Transbilayer asymmetry is a general feature of most lipids in the plasma membrane and other post– endoplasmic reticulum organelles. This asymmetry has important consequences for membrane physical properties and cell signaling. Although cholesterol is a major lipid in these membranes, its transbilayer distribution is not well understood. Using fluorescent sterols (dehydroergosterol and cholestatrienol) and a variety of fluorescence quenchers, the authors determined that the majority of sterol is in the cytoplasmic leaflet of the plasma membrane and endocytic recycling compartment of CHO cells. Quenchers that are restricted to the exofacial leaflet of the plasma membrane reduce the fluorescence intensity by about 20%–30%, whereas microinjection of quenchers into the cytosol quenched the fluorescent sterols associated with the plasma membrane and endocytic recycling compartment by about 60%. The presence of high amounts of cholesterol in the cytoplasmic leaflet might have important implications for intracellular cholesterol transport and for membrane domain formation.

Genetic Hypervariability in Two Distinct Deuterostome Telomerase Reverse Transcriptase Genes and Their Early Embryonic Functions Trystan B. Wells, Guanglei Zhang, Zenon Harley, and Homayoun Vaziri Within a species of complex animals, genes for functional proteins are rarely variant. This constancy is thought to be required for the function of essential proteins. One such crucial protein is telomerase reverse transcriptase catalytic subunit (TERT). To study the function of TERT during early development, the authors cloned SpTERT from purple sea urchin embryos. Unexpectedly, they discovered two distinct telomerase genes named SpTERT-S and SpTERT-L. By cloning SpTERT from several individuals, they further discovered regions, especially exon 11 of SpTERT-S, with intraspecific germline hypervariability. Although the variant enzymes remained catalytically active, there were significant amino acid variations in multiple regions, including those involved in binding of TERT to its RNA component. The authors also uncovered a noncanonical essential function for telomerase that is required for embryo polarity at the mesenchymal blastula stage. These results suggest the presence of an active diversity-generation mechanism that has neofunctionalized telomerase throughout evolution.

The Aspergillus nidulans Kinesin-3 UNCa Motor Moves Vesicles along a Subpopulation of Microtubules Nadine Zekert and Reinhard Fischer The microtubule cytoskeleton is not as rigid and uniform as the name implies, but is characterized by its dynamic instability. In addition, microtubules can be made up of different tubulin isoforms and—to make a eukaryotic cell even more complex—of different posttranslationally modified tubulins. Microtubule modifications, such as acetylation or polyglutamylation, are evolutionarily old “inventions” and occur in primitive eukaryotes such as Giardia lamblia, whereas detyrosination appeared later during evolution. Although many modifications were discovered more than 20 years ago, their cellular functions are not well understood. Here, the authors show that in the filamentous fungus Aspergillus nidulans at least two different microtubule populations exist. This discovery came from studies of an unc-104–related motor protein that preferentially moves along detyrosinated microtubules and transports vesicles. These microtubules are more stable than the tyrosinated ones and even remain intact during mitosis when other cytoplasmic microtubules are degraded.

Competitive Nuclear Export of Cyclin D1 and Hic-5 Regulates Anchorage Dependence of Cell Growth and Survival Kazunori Mori, Etsuko Hirao, Yosuke Toya, Yukiko Oshima, Fumihiro Ishikawa, Kiyoshi Nose, and Motoko Shibanuma Anchorage dependence of cell growth is a critical trait that distinguishes nontransformed from transformed cells. The authors report a novel mechanism whereby anchorage-independent cell growth and survival is prevented. Cyclin D1 is a proto-oncogene that exhibits cell cycle– dependent nuclear localization. Its nuclear export is dependent on CRM1. The authors report that the nuclear localization of cyclin D1 is adhesiondependent and regulated by the focal adhesion protein Hic-5 and its binding partner PINCH, which also cycle in and out of the nucleus. Hic-5 binds to CRM1 with high affinity and is a competitive inhibitor of CRM1-dependent cyclin D1 export in adherent cells. PINCH interacts with both cyclin D1 and Hic-5 and enhances the Hic-5–dependent inhibition of cyclin D1 export. Under nonadherent conditions, the cellular level of reactive oxygen species increases and inhibits the nuclear export of Hic-5, resulting in the nuclear export of cyclin D1. Consequently cells undergo growth arrest and apoptosis. Ras overexpression led to the anchorage-independent nuclear localization of cyclin D, revealing an interesting interdependence of the oncogenic potential of two oncogenes. n JANUARY 2009 ASCB NEWSLETTER

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PUBLIC POLICY Briefing Dingell vs. Waxman: A Battle of Titans Only days after the 2008 congressional election, newly elected House Democrats had to cast what could be the toughest vote of their congressional careers—who to support for chair of the House Energy and Commerce Committee. For the soon-to-be members of Congress, supporting the wrong candidate Rep. John Dingell (D-MI) could doom their legislative careers before they even start. The House Energy and Commerce Committee is the oldest and most powerful

committee in the House of Representatives. It has jurisdiction ranging from biomedical research and the National Institutes of Health (NIH) to U.S. energy policy and travel and tourism. Rep. John Dingell (DMI) has served as the chair or senior Democrat on the Energy and Commerce Rep. Henry Waxman (D-CA) Committee since 1981. As the longest-serving member of the House, first elected in 1955, Dingell is also the Dean of the House of Representatives.

The Challenge In the days following the 2008 election, Rep. Henry Waxman (D-CA) announced that he would challenge Dingell for the chairmanship of the Energy and Commerce Committee. Waxman, first elected in 1974, currently serves as chair of the House Oversight and Government Reform Committee. That is the main investigative committee of the House, but it has no legislative powers. Waxman won the battle of congressional titans 137–122. While Waxman will continue to be supportive of the NIH in his new position, he may also continue to use his investigatory skills in his new oversight role. NIH-related issues that will confront the Waxman-led committee include reversal of the Bush policy on federally funded stem cell research, NIH reauthorization, and ongoing congressional concern about scientific conflict of interest. n —Kevin M. Wilson

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ASCB NEWSLETTER JANUARY 2009

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NEW FROM NATURE PUBLISHING GROUP

Scitable is an educational website offered by Nature Publishing Group for educators who want to help students develop a deeper comprehension and appreciation of science. Scitable is a free resource for both faculty and students. An up-to-date, steady stream of undergraduate-level educational overviews from the editorial staff of Nature Publishing Group ensures that genetics & biology educators and their students will have easy access to a reliable source of evidence-based information.

Scitable currently features content in genetics, including: chromosomes and cytogenetics, evolutionary genetics, gene expression and regulation, genes and disease, gene inheritance and transmission, genetics and society, genomics, nucleic acid structure and function, population genetics and much more. To learn how you can engage students by exposing them to reliable, evidence-based content and thought-provoking discussion, visit www.nature.com/scitable today.

www.nature.com/scitable ©2008 nature EDUCATION

The American Society for Cell Biology gratefully acknowledges the following Society members who have generously donated to the ASCB Half-Century Fund.* These 2008 Half-Century Society members are helping to support the Society’s continued innovation.

Gold Bruce Alberts Richard Anderson Craig Blackstone Marilyn Farquhar Christine Field Tim Mitchison Suzanne Pfeffer Susan Wente

Silver Joseph Besharse Qingshen Gao Morris J. Karnovsky

Bronze Diana C. Bartelt (in memory of Dr. William D. Cohen) Henry G. Brown Silvia Corvera Paul Forscher Richard Hynes Shinya Inoue George Langford Daniel J. Lew Eva Nogales Thoru Pederson William Saxton Jonathan Scholey Jean Schwarzbauer Masatoshi Takeichi Earl H. Weidner

Sustainer Donald Brown Coralie A. Carothers Carraway Cyril E. Challice Shu Chien Alan L. Epstein Alan F. (Rick) Horwitz Yasunori Kitamoto Geri Kreitzer Phoebe S. Leboy Gloria Lee James C. Lee Vincent T. Marchesi Pierre D. McCrea W. Sue Shafer Amy Tang William B. Wood Howard Worman Xin Xiang Masaki Yanagishita

* At press time, since the December Newsletter listing JANUARY 2009 ASCB NEWSLETTER

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Update Your Contact Info Today! We want to make sure you’re kept up-to-date on all the latest ASCB news and events. That means we need your most recent contact information. It’s easy to update this information on our website: n n n n

Go to www.ascb.org and click on “Members Only” at the top of the page. Click “Update Profile” and enter your Username and Password. To update your address, email, or phone number, click “Main” under Address Type. Enter your changes, click “Continue” and then “Save.” It’s that easy!

If you have any questions, contact the ASCB at (301) 347-9300 or [email protected]. n

Research Residency for Biology Scholars Have you ever wondered if your teaching approaches are effective? Have you considered investigating your own teaching practices? Would you like to improve your teaching and its impact on student learning? If so, consider applying for the National Science Foundation– supported Biology Scholars Program Research Residency (www.biologyscholars.org). The application deadline for the Research Residency is March 1, 2009. More details about the program and application process are available below and at the website: www.biologyscholars.org/ page02c.shtml. The Research Residency is a year-long program that begins with a Scholarship of Teaching and Learning (SoTL) Institute in Washington, DC, July 15–18, 2009. The SoTL Institute is an intensive program designed to help faculty learn how to conduct research in teaching and learning in the biological sciences with improved pedagogy practices and student learning outcomes. Space is limited to 20 scholars. n

University of Virginia 4th Biennial Morphogenesis Symposium May 27-29, 2009 www.morphogenesis.virginia.edu 22

ASCB NEWSLETTER JANUARY 2009

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The ASCB Appreciates Its 2008 Corporate Members Gold

The ASCB Gratefully Acknowledges the Following 2008 Annual Meeting Supporters Bristol Myers Squibb Research and Development Undesignated The Burroughs Wellcome Fund Minorities Affairs Committee and Career Discussion Lunch

BD Biosciences Roche Applied Science

silver

Cadmus Communications, A CENVEO Company MBC Editorial Board Dinner Chroma Technology Corporation Undergraduate Student Travel Awards

Biogen/Idec Chemometec A/S Chroma Technology Corporation Leica Microsystems Millipore Corporation

Cytoskeleton, Inc. Minisymposium 20: Cellular Response to Infectious Agents

The Ellison Medical Foundation Translating Progeria: A Benchto-Bedside Story

Elsevier Childcare Awards

Garland Sciences-Taylor & Francis Group Undesignated

Nikon Instruments, Inc. Novare Biologistics Olympus America, Inc.

Genentech, Inc. Message Center and Speaker Lounge JEOL USA, Inc. Undesignated

Point Source Veeco Instruments

JANUARY 2009 ASCB NEWSLETTER

National Institute of General Medical Sciences Minorities Affairs Committee Activities National Eye Institute, NIH Minisymposium 10: Cell Biology of the Synapse

Nature Publishing Group Morning and Afternoon Refreshment Breaks and Educational Resources/ Minorities Affairs Committee Booth Nikon Instruments, Inc. CellSlam 2008: SF Shoutout!

Office of Research on Women’s Health, OD, NIH Workshop Offered by the WICB Committee

THE ELSEVIER FOUNDATION

BRONZE Corning Incorporated

National Institute of Environmental Health Sciences Undesignated

Merck Research Laboratories Minisymposium 16: Signaling from the Extracellular Matrix Minisymposium 21: Genomic Instability and Cancer

Olympus America, Inc. Lanyards

Optical Imaging Association Subgroup B: At the Limits: Optical Methods for Single Molecules, Cells, and Organisms Roche Applied Science Notepads

The Rockefeller University Press/ The Journal of Cell Biology Norton B. Gilula Memorial Award

Worthington Biochemical Corporation Predoctoral Student Travel Awards

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MEMBERS in the News Mina Bissell of Lawrence Berkeley National Laboratory, an ASCB member since 1973 and 1996-97 ASCB President, and Susan Band Horwitz of Albert Einstein Medical College, an ASCB member since 1980, are two of the Mina Bissell Susan Band four recipients in 2008 of the American Horwitz Cancer Society’s highest honor, the Medal of Honor. Bissell received the Medal of Honor for Basic Research; Horwitz received the Medal of Honor for Clinical Research. Michael D. Ehlers of Duke University Medical Center/ HHMI, an ASCB member since 2000, won the 2008 Life Sciences Achievement Award for Breakthrough Research. The award is given jointly by the North Carolina Biotechnology Center and the National Multiple Sclerosis Society. Joachim Frank of Columbia University/HHMI, an ASCB member since 1998, was one of the recipients of the 2008 George E. Palade Gold Medal from Wayne State University for his research with Thomas A. Steitz on ribosome structure and function.

Alfred Goldberg of Harvard Medical School, an ASCB member since 1993, was awarded the 2008 Jacob Heskel Gabbay Award for Biotechnology and Medicine by Brandeis University.

Susan Lindquist of the Whitehead Institute for Biomedical Research, an ASCB member since 1983, is the recipient of the 2009 Ralph and Helen Oesper Award from the American Chemical Society.

Sandra Mayrand of the University of Massachusetts Medical School (UMMS), who first joined ASCB in 1982, was one of the recipients of the 2008 Manuel Carballo Governor’s Award for Excellence in Public Service. Mayrand, who is director of the UMMS’s Regional Science Resource Center, received the award for her extraordinary contributions to science and math education in Massachusetts. Correction: In the November 2008 Members in the News, Peter Novick’s affiliation was incorrect. He is in the Department of Cellular and Molecular Medicine at the University of California, San Diego.

Treasurer’s Report Correction The total printed for ASCB’s audited expense in Short Year 2007 (the nine-month fiscal year ending December 31, 2007) in the December ASCB Newsletter was incorrect. The correct total is $4,930,276.

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ASCB NEWSLETTER JANUARY 2009

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MEMBER Gifts The ASCB is grateful to the following members and applicants who have recently given a gift to support Society activities: Richard L. Blanton

Yuko Mimori-Kiyosue

Rebecca S. Boston

W. James Nelson

Ann Hart Erickson

Thomas D. Pollard

Harrison W. Farber

Edward D. Salmon

Marvin J. Fritzler

David R. Samols

Susan A. Gerbi

Lindsay Susan Shopland

Walter N. Hittelman

Edwin M. Uyeki

Lynne Ann Lapierre

Clare M. Waterman

R. John Lye

David A. Weisblat

Michael J. Matunis

Keith R. Yamamoto

Carrie J. Merkle

MariaElena B. Zavala

John R. Merriam

The ASCB wishes to express deep appreciation to all the exhibitors who attended the 2008 Annual Meeting and helped ensure its success.

JANUARY 2009 ASCB NEWSLETTER

ELSO Fuses with EMBO For the past 10 years, ELSO, the European Life Scientist Organization, has hosted an annual international congress. The 2008 ELSO Meeting, organized jointly by ELSO and the European Molecular Biology Organization (EMBO), in Nice last summer was the 7th and last ELSO meeting. ELSO is now being incorporated into EMBO. “We now need a structure that is more sustainable to carry the meeting forward into a new era,” says Kai Simons, ELSO President. Established in 1964, EMBO has focused on recognizing and fostering talented scientists, disseminating knowledge, and stimulating cooperation across borders. The fusion of ELSO and EMBO sets the stage for the EMBO Meeting in 2009, in Amsterdam. n

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UNIVERSITY OF VERMONT FACULTY POSITION VERMONT IMMUNOBIOLOGY / INFECTIOUS DISEASES CENTER The Vermont Immunobiology / Infectious Diseases Center is undergoing significant expansion and is seeking an outstanding tenure-track faculty member at the Assistant, Associate or Full Professor level to contribute to the Center’s research and teaching programs. Candidates appointed at the level of Assistant Professor may be eligible for research funding from a recently awarded NIH Center of Biomedical Research Excellence (COBRE) Award. We are seeking a scientist with a demonstrated research track record and an innovative research program in the areas of microbial/viral pathogenesis or immune response to infectious agents. Extensive opportunities for collaborative research exist within and outside the Center in cell, molecular and structural biology. Primary appointment will be in the Department of Microbiology and Molecular Genetics. Details about the Center, the Department, the University and the Burlington area may be accessed at http://www.med.uvm.edu/vcii and http://www.uvm.edu/microbiology/ mmg_home.php. A curriculum vitae, a summary of research interests and three letters of reference should be sent electronically (if possible) to: Search Committee Chair, c/o Ms. Debra Stern ([email protected]), 201 Stafford Hall, University of Vermont, 95 Carrigan Drive, Burlington VT 05405, or apply online at: https://www.uvmjobs.com/applicants/jsp/shared/frameset/Frameset. jsp?time=1170944834156. Review of applications will begin immediately and continue until a suitable candidate is identified. The University of Vermont is an equal opportunity, affirmative action employer. Women and under represented minorities are encouraged to apply. JANUARY 2009 ASCB NEWSLETTER

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New Members The ASCB Council admitted 1,635 new members and granted Emeritus status to 8 members of the Society last month: Monika Abedin Maria Abramow-Newerly Elliott Warren Abrams Seyda Acar Melanie R. Adams Georgina Boakyewaa Addae Ruth Oluwatoyin Adekunle Eric Kwabena Afoakwah Qurratulain Aftab Shivangi Agarwal Shivani Agarwal Jin Hyun Ahn Juhyun Ahn Molly J. Ahrens Yoshikatsu Aikawa Adebunmi B. Akinkuotu Adewonuola Adelodi Alase Kurt H. Albertine Mistre Alemayehu Irina Alexandar Adrian Douglas Allen Shabeen Ally Anisah Alyahya Sunitha T. Ambikapathi Jaejin An Graham A. Anderson Johnathon David Anderson Michael Andrew Anderson Meghan Andes-Koback Mihaela Anitei Quintabella Fri Anjeh Sarah Daniela Appel Tomas Aragon Delphine Arcizet Thomas Armel Julia Arpino Cristina R. Artalejo Nick Asbrock Marc P. Ascione Christopher Ashwell Andrea Asimoglou Chaitanya Anil Athale Nicanor Austriaco Petri Auvinen Junya Awata Daniel Aydin Behrad Azimi Juliette Celine Azimzadeh Atya Aziz Joanne Robyn Babb David Bader Munsook Bae Yong Ho Bae Eun Jung Baek Felix Baerenz Julie E. Baggs Clive Richard Bagshaw Shirin Bahmanyar Bingxue Bai Galina Baibakov Charvann Khamille Bailey Kanika Bajaj Sundaravadivel Balasubramanian Cristiani Baldo Eric Balzer Debarshi Banerjee Mithu Banerjee Masaki Bannai Somesh Baranwal Rebecca S. Bart Sadie Rae Bartholomew Anupama Barua Martine Bassilana Lance A. Batchelor Ammon Hansen Bayles Kimberley Anne Beaumont Matthew Edward Bechard Natalya Belkina Khadija Ben-Aissa 32

Jennifer Benanti Kfir Ben-Harush Federica Benvenuti Svitlana Berezhna Sarah Elizabeth Bergeron Kiflu Berhane Dan Richard Beriault Laura A. Berkowitz Anne Bernheim Jessica Bessler Ioanna Bethani Gev Singh Bhabra Prem L. Bhalla Ruchi Bhalla Ashima O. Bhan Kavita Purnanda Bhat Purnima Bhat Nidhi Bhutani Rea Erika Biacsi Shengjie Bian Kirsten Adele Bielefeld Prabath Gopalakrishnan Biju Daniel D. Billadeau Luis Santos Bimbo Lacramioara Bintu Alexander W. Bird Stephen Lucien Bird Nicholas Holdaway Bishop Julie Suzanne Biteen Ronnie Blazev Leo S. Bleicher Christopher Boehlke Ralph Thomas Boettcher Erich T.A. Boger Hana Lee Bohmer Stephen Raymond Bond Carine Bonnon Dustin L. Boothe Terri Borree Pinaki Bose Francesca Bottanelli Beth Bouchard Rajaa Boujemaa-Paterski Rachel Victoria Bowie Anna Marina Brachet Niels Bradshaw Jennifer Jean Brady Sharon Clare Braunagel Javier Bravo Dennis Breitsprecher Audrey Brenot Daniel Stuart Brereton Laura Marie Breshears Patricia A. Bresnahan Christopher L. Brett Laurie H. Brier Alison Bright Jelena Brkljacic John Brognard Steve G. Brohawn Eric R. Brouzes Frank Curtis Brown Kanika Z. Brown Scott Brown Carlo Brugnara Julie Buchheim Abigail L. Buchwalter Kenneth Buck Richard Buckholz Sadna Budhu Annika Budnik Matthew Buechner Catherine Bui Duyen (Amy) Kieu Bui Johanna Buisson Feliksas Bukauskas Thomas Allen Bunch Patricia Andressa De Almeida Buranello Tessa Burch-Smith

Patrick Gary Burgon Jason L. Burkhead Christopher Buser DeMario Montez Butts Amber R. Buz’Zard Na Cai Giusi Caldieri Joseph Paul Campanale Erin McCarthy Campbell Jian Cao Mian Cao Qi Cao Yang Cao Daniel Capurso Wendy Cristina Carcamo Juan Manuel Cardenas-Mora Sandra Morais Cardoso Michael Carlsson Marc Julian Carmichael Elysia M. Carnagey Lucinda Carnell Meredith Lauren Carpenter Letizia Carramusa Michael D. Carrithers Christopher Carroll Susheela Carroll Lucy Cassar Barbara Jones Cassin Luis Alberto Castro-Sanchez Luis Andrés Cea Fabiola Cecchi Steven Joseph Celetti Silvia Cermelli Shawn Chafe Mathilde Chaineau Annie Chamberland Chi Ping Chan Manasa Chandra Vidya Chandrasekaran Kshama Chandrasekhar Ching-Fang Chang Jeremy Chang Robert C. Chang Wei-Tien Chang Belle Chang-Ileto Mark P. Chao Tzu-Yuan Cindy Chao Hannah Cole Chapin Alanna Mary Chaudhry Gautam Chaudhuri Anne Chauveau Cheng-Nan Chen Jennifer A. Chen Jichao Chen Jing Chen Jue Chen Kuan-Yu Chen Liangyi Chen Lixiang Chen Meng Chen Nan Chen Pan Chen Ping-Hung Chen Po-Cu Chen Ruey-Hwa Chen Siyu Chen Tzu-Chi Chen Wan-Chun Chen Yiliang Chen Aaron Cheng Tsai-Chen Chiang Satyarebala Chilaka Brian Chin Der-Hang Chin Pei-Ju Chin Irene Chiolo Nion Chirapongsatonkul Cathleen Chiu Kyongshin Cho Kyu-Suk Cho

Kwang-Min Choe Byung-Kwon Choi Chang-Hoon Choi Chang-Soon Choi Eun Young Choi Hye Jin Choi Jin-Ok Choi Kyoung-Han Choi Min Sik Choi Ray Sung Choi Seonkyu Choi Wen-Hai Chou Jacqueline Chretien Calvin Chu Patrick Y.W. Chu Peiying Chuan Carol Chuang Han-Yu Chuang Sean Chun Chin Ha Chung Murat Cirit Ami Citri Dennis Reed Clayton Cristina Corina Clement Leah Jean Clemmer Robin Annette Cline Kimberly Cochrane Miguel Costa Coelho Mary Cole Diane Colello Catherine A. Collins Richard Frederick Collins Pamela F. Colosimo Paul Thomas Conduit Barbara Elizabeth Coons Elizabeth Corpuz Matthias Corrotte Brett Charles Couch Catharina Irene CrammBehrens Jonathan Crane Viviana Cremasco Justin Crest Stephanie Denise Crockett Laure Croisille Alison Crowe Narcisa L. Cunha-e-Silva Kevin Enda Cunningham Erin Currie Ian Cushman Daniel Czerny Claudia Dall’Armi Vesna Damljanovic Erich William Damm Andrew John Darr Madhumita Das Maitreyi Das Satyabrata Das Shreyasi Das Sutirtha Datta Cori Ann D’Ausilio Daryl J. David Alex E. Davies Aaron Patrick Davis Emily A. Davis Toni Renee Dawson Damon Nino De La Cruz Flavia De Paoli Valérie De Rop Debabrita Deb-Basu Erik Werner Debler Mark A. DeCoster Maika Sherone Deffieu Catherine R. Degnin Susana Del Olmo Aguado Ryan William Demers Phillip Dennis Angela DePace Dmitry N. Derkach Jigar R. Desai

Rachel Marie DeVay Bob Andrew Deziel Sascha Dho Rohini P. Dhulipala Vikram Dhuna Valeria Elisabetta Di Giovanni Joshua Dias Jessica Diaz Daniel J. Dickinson Martina Dieber-Rotheneder Michael Diehl John T. Dimos Colin Jelinek Dinsmore Serge Dmitrieff Ryan Doan Iveta Ivanova Dobreva Hartmut G. Doebel Anne Paulus Doeskeland Stein Ove Doeskeland Nicholas James Dolman Simona Donatello Erin Wynter Donovan David Bagon Doroquez Christine Doucet Max Douglas David Patrick Doupé Josette Douville William Eric Dowdle Daniela Drummond-Barbosa Zhou Du Erning Duan Yuan Yuan Duan Evemie Dubé Andrew Thomas Dudley Stanimir Dulev Julien Dumont Alexander Robert Dunn Joanne Durgan Vincent Duronio Gennaro D’Urso Jordan Eboreime Karen Echeverri Maria C. Edman Sara Edwards Ayaka Eguma Sarah Ehses Roselyn J. Eisenberg Tzipora-Sara Karin EisingerMathason Candice Antionette Elam Gerard Elberg Amr Eldakak Marina Lyn Ellefson Imogen A. Elsum Mary Williard Elting Kimberly A. Elwood Amber Rex English David M. Engman Herve Enslen Elizabeth A. Erickson Vivian Russell Ericson Albert J. Erives Nika Erjavec Christopher Esk Jeffrey J. Essner Carlene Sheree Eteveneaux Holly Evans Timothy Martin Evans Amy S. Fabritius Oliver Till Fackler Isabelle Anne Claire Faglin Jennifer Fang Shengyun Fang Ali Farkhondehpour Claire Ann Fassio Christian Herbert Faul Vincenzo Favaloro Rodolfo Ribeiro Favaro David Feder Martina Fellner

ASCB NEWSLETTER JANUARY 2009

Alicia Felthauser Jue Feng Rebecca S. Fenn Norvin Fernandes David Michael Ferrari Priscila Santos Ferreira Morgan Kimberly Fields Peter Filipcik Aristotelis Filippidis NiCole Ann Finch Kari Leigh Fine Darren Finlay Kenneth John Finn Elif Nur Firat April Fischer Robert S. Fischer Elizabeth Suzanne Fisher Michael Fiske David Flores Marina E. Fomin Edward A. Fon Catherine Foo Amy Beth Foraker Tetyana Forostyan Farshad Forouzandeh Lina Emilia Fortelius Rebecca M. Fox Fouad Francis Heather Lee Francis Juan Francisco Christian Ray Francom Anna Franz Michael Fraser Alexandra Fridkin Jonathan Friedman Jianping Fu Min Fu Xueyao Fu Morihisa Fujita Masayuki Funaba Chloe Marie Funkhouser Leon A. Furchtgott Marian Gaballah Maytal Gabay Cheryl Ann Gale Manuel Galinanes Timothy Galitski David Gan Vidyaramanan Ganesan Karuna Ganesh Anutosh Ganguly Yong-Guang Gao Elvin L. Garcia Mariel Alexandra Garcia Lisbeth Libertad García Alicia Garcia De Galdeano Emily Gardel Stéphane Gasman Alexis Gautreau Gerhard Geipel Rita Gelin-Licht Cristy Lee Gelling Luciana Boffoni Gentile Maria-Magdalena Georgescu Angela Ghatnekar Shervin Ghorab Prachi N. Ghule Elizabeth M. Gibbs Renee M. Gilberti Julia K. Gilden Ciara Chantel Gimblet Claudiu Giurumescu Carlotta A. Glackin Lyudmyla P. Globa Nathan Goehring Keryn Gold Aaron Robert Goldman Claire Goldsbury Alexandra M. Goldyn Javad Golji Christopher R. Gomez Esther Winter Gomez Timothy S. Gomez Veronica Gomez Yanira Gonzalez-Berrios Miranda Elizabeth Good Kenneth Eugene Goodell

Radhika Gopal Matthew P. Gordon Roman Gorelik Michael Gotesman Tetsuya Gotoh Douglas B. Gould Ellie Graeden Amy C. Graham Jacob S. Grange Lisa Diane Grantham Emily Sarah Grau Amelie Gravel Marcia Lynn Graves Diane Renee Gray Gary Owen Gray Erin Green Mary Elisabeth Greene Mary Gregory Genevieve S. Griffiths Karlheinz Grillitsch Paula Marie Grissom Angela Lynn Groehler Kathryn Marie Gronlund Line Groth-Pedersen David Gruenwald Oliver Johannes Gruss Bingnan Gu Marc-Jan Gubbels Radhika Raghunath Gudi Adrian Dilan Gunaratne Teresa M. Gunn Chin-Lin Guo Jiayan Guo Elizabeth Christel Gutierrez Natasha Gutierrez Jeff Habig Saori Haigo Somer Hall Stephen G. Hall Peter Hamm Joo-Seok Han Sungwon Han Alison Jean Hanson Manoj Hariharan Hans Harn Nicola Harper Adam John Harrington Kenneth D. Harrison Sean Michael Hartig Camila Arantes Hartmann Jill Shizuko Harunaga Toshiyuki Hatano Zachariah J. Hawkins Jennifer Haynes Yungui He Brian Head Nastaran Heidari Doris Marianne Heinrich Paul Glenn Held Scott Dylan Henderson Anastasia Henry Jonathan V. Henzel Carmen Isabel Hernandez Sergio Hernandez Mary Elizabeth Herndon Thomas Heuser Christopher Higgins Michelle D. Hines Masaki Hiramoto Akinori Hishiya Chin Yee Ho Chin-Min Ho Li-Lun Ho Lynda Mai Hoang Courtney Hodges Carsten Hoege Maja Beate Hoegg Oliver Hoeller Andre Hoelz Piper Lee-Wycoff Hollenbeck James Hollenhorst Nancy Marie Hollingsworth Julie Holsclaw Peter Hornbeck Babak Hadji Hosseini Takashi Hotta John E. Houghton

JANUARY 2009 ASCB NEWSLETTER

Edward C. Hsiao Chung-Hsi Hsing Guoku Hu Qicong Hu Xiaoxiao Hu Bo Huang Carol Huang Hsiao-Chun Huang Juan Huang Kerwyn Casey Huang Lily Huang Yue-wern Huang Helen Hughes Won-Ki Huh Elliot E. Hui Keren Isaac Hulkower Greta Hultqvist Julie Hunkapiller JoAnn G. Hunter Michael Hunter Moonsun Hwang Yoo-Seok Hwang Richard Tonye Ibitamuno Yoshikazu Imanishi Evan Ingley Luke A. Ingraham Jamie L. Inman Kenji Irie Nurzian Ismail Mikako Ito Takashi Itoh Olena Ivashyna Joanne S. Jacob Roland Jacob Frank Jacobs Christian B. Jacobson Jana Marcette Jacobson Benoit V. Jacquet Lionel Francis Jaffe Fereshteh Jahaniani Sandhya Jain Emma Jakobsson Farid Jalali Prasad Jallepalli Yousef Jamali Swadhin Chandra Jana Jin Sun Jang Mihue Jang Divyang Jani Swaathi Jayaraman Karthikbabu Jeganathan Devon Jensen Pernille Linnert Jensen Se Jin Jeon Min Seop Jeong Kristin Jernigan Baohua Ji Erin Alisa Jimenez Fang Jin Fengzhi Jin Hua Jin Huajun Jin Jing Jin Natsuko Jin Yui Jin Zheng-Gen Jin Lili Jing Christopher David Jingle Katerina Jirsova Jeanne Nicole Jodoin Jennifer Linda Johnson Kristen E Johnson Stephanie Lynn Johnson Anna-Karin Erika Johnsson Aaron David Johnstone Scott Robert Johnstone Kristen Allen Jones Raisa E. Jones Steven Robert Jones Martin Casimir Jonikas Tijana Jovanovic-Talisman Marilyn Juarez Daria Julkowska Juan E. Jung Yajima Junichiro Krista Kaasik Hiroaki Kajiho

Rieko Kanda Dong Soo Kang Ho Jin Kang Jihee Lee Kang Sang Hyeon Kang Gregory Kanhai Fumi Kano Hung-Ying Kao Richard Kao Yuan-Chung Kao Jana Karbanova Jennifer A. Karcz Feridoun Karimi-Busheri Thommie Karlsson Marcela Karpuj Roshni Kasad Susan Kasper Hiroshi Katayama Junko Kato Yoko Kato Gurpreet Kaur Bwarenaba Bareta Kautu Takayuki Kawachi Nanako Kawaguchi Hiornori Kawahara Taisuke Kawamoto Aynur Kaya Brian Keady Michael G. Kearse Jamie Keck Yee Seir Kee Andras Miklos Kengyel Ronald Kern Albert Jun Qi Keung Kirstin Keusekotten Mohammed Abdul Sattar Khan Hemant Khanna Marianna Kharchenko Davitte Khauv Rustam Khodjayev Andrei Khokhlatchev Shariq Khwaja Antje Kiesewetter Bok-Geon Kim Cho Hee Kim Haesun A. Kim Hong Seok Kim Hyung-Do Kim Ki Chan Kim Kyeong Kyu Kim Si Wan Kim Soya Kim Tae Young Kim Won Ho Kim Young-Myeong Kim Jonathan M. King Viktor Kirik Takuma Kishimoto Ophir David Klein Jonathan Knight Markus Knop Agnieszka Kobielak Krzysztof Kobielak Thorsten Michael Koch Eva Koegler Stefan Andreas Koestler Cheng-Gee Koh Takao Kohno Kevin Sohail Kolahi Justin M. Kollman Zhaosheng Kong Cornelia König Masha Kononov David L. Kooyman Till Korten Hidetaka Kosako Chitra Kotwaliwale Robert Kovelman Jessica Lee Kowal Susanne Kramer Dragomir Blazhev Krastev Rachel Susan Kraut Jeremy Kreher Barbara Ballard Kreutzer Moorthy Krishnan Stine Gry Kristensen Vanja Krneta-Stankic

Cornelia Kroeger Brooke Krovic Irene Kuhn Neeraj Kulkarni Ashok Kumar Deepti Lava Kumar Ambarish Kunwar Cheng-Hsiang Kuo Dian-Han Kuo Jeremy Keith LaBarge Carole LaBonne Sylvain Lacomble Markus Ladwein Cary Lai Chunfai Lai Zhenyang Lai Zhong-Fang Lai Vibor Laketa Danielle Lalimar Vinh Lam Kyle Evan Landgraf Peter Ronald Langford Jason Lanman Deborah A. Lannigan Davin Larsen Matthew H. Larson Yee Ling Lau Jane Elizabeth Lauckner Brigitte Denise Lavoie Yuen Kwan Law Ana Lazic Dung Hong Le Minh Thi Nguyet Le Thuc T. Le Marisa Ann Leal Cecile Leduc Connie M. Lee Eun Sun Lee Gwanghee Lee Hansoo Lee Hsiao-lu Lee Hye Jin Lee Hyo Sun Lee Laura Anne Lee Mi Hee Lee Mi-Hye Lee Min Jung Lee Ming Hin Lee Myoung Hui Lee Pedro Lee Peter Lee Samuel Kyle Lee Sangho Lee Sang-Hyun Lee Sumin Lee Sung-Chang Lee Sunghoon Lee Sun-Young Lee Wonhee Lee Ya-Jung Lee Yeom Pyo Lee Yin Loon Lee Abigail Leeder Andrea Leibfried Alline M. Lelis Lisa Lenertz Kerry Ann Lepley Christophe Leterrier Sanford Leuba Tsz Ki Leung Sima Lev Steve Marcel Levesque Daniel L. Levy Vered Levy Aiqun Li ChaoJun Li Hoi Y. Li Huashun Li Jing Li Long-Yuan Li Pingxin Li Wan-Ju Li Wei Li Wing Man Michelle Li Xiaodong Francis Li Yan Li Yuwei Li 33

Zhichuan Li Yuying Liang Jung-Chi Liao Ian Liau Pui Yi Pearl Lie Gareth Lim Ding-Yen Lin Guo Rui Lin Hsi-Hui Lin Wan-Hsin Lin Xianming Lin Mariana Pina Lince-Faria Geoff Paul Lin-Cereghino Emma Lindahl Timothee Lionnet Imke Listerman Joy L. Little Chang Liu Chi-Hsin Liu Dan Liu Li Fen Liu Wei Michael Liu Yu-Wen Liu Geulah Livshits Jun-Chih Lo Sheng-Ying Lo Frances Lock Rebecca Charlene Lock Sven Loebrich Sheila M. Logan Martin Loignon Beata Lontay Trina Jane Loos Luis Fernando López Esther Lopez-Rivera Ferdinand Los Kaylen Beth Lott Ilia Louban Rose Loughlin Maggie C. Louie Regine Low Maria Adelia Luca Laura Luettjohann Yvonne Lussi Aracely Lutes Hinh Ly Erik Allen Lykken Deirdre Colleen Lyons Jenny Ma Lawrence Mabasa Alasdair Iain MacDonald Steven Alfred Machtaler Joanna Lynn MacKay Anne-Marie Madore Shingo Maegawa Jordi Magrane Kirti Magudia Katrin Mair Charlotte Maisonneuve Jason Bradley Malone Joshua Malouin Irina Malyukova Cornelia Man Joel Mancuso Atin Kumar Mandal Sailaja Mandalapu Uri Manor Daphne Manoussaki Hanqian Mao Mao Mao Yingyu Mao Deanna Marchionini Pablo Mardones Steven Matthew Markus Pierre-Marie Edern Martin Luke Martin McCaffrey Maria Guadalupe Martinez Itziar Martin-Ruiz Vilma Martins Yoshiro Maru Ravi Maruthachalam Ed B. Maryon Murata Masayuki Fred David Mast Michael B. Mathews Richard T. Mathias Yuka Matsushita-Ishiodori 34

Steven Douglas Maxfield Mirjam Mayer Janielle Petrolla Maynard Jessica Nicole Mazerik Damara McAndrew Andrew Jeffrey McCluskey Mark Ian McDermott Katie McDole Richard McGee Tanisha Zamore McGlothen Richard James McKenney Jeanne McKeon Andrew Robert McKinley Nicole C. McKnight Sarah Elizabeth Anne McLean Chayapathy Meghana Roland Meier Thomas E. Meigs Ana M. Meireles Barbara Mellone Malwina Mencel Ariadna Mendoza Naranjo Prashanthi Menon Linet Mera Stanislava Merjava Julie Ann Merkle Philip Merksamer Ronald Merrill Rebecca A. Meseroll Mallikarjuna Reddy Metukuri Carissa Bove Meyer Xavier Michalet Alphée Michelot Takashi Miki Karl E. Miletti-Gonzalez Miroslav Petrov Milev Lawrence W. Miller Marion G. Miller Danielle Miranda Ryo Misaki Nandita Mishra Jana M. Mitchell Megan L. Mittelstadt Haruhiko Miyata Di Mo Annamaria Mocciaro Nicole Molinos Anahi Molla-Herman Perry S. Mongroo Eun-Kyung Moon Yuseok Moon Victoria Del Gaizo Moore Cristina Drummond Moreira Joshua Thomas Morgan Hiroki Mori Koichi Morimoto Benson Morrill Erin Morris Holly Morrison Meghan Ann Morrissey Theodor Michael Morrow Lesetja Raymond Motadi Eduardo Moura Elisabete Ferreira Da Silva Moura Ruhollah Moussavi Baygi Katherine Moynihan Rana Mroue Dolores D. Mruk Hannah Mueller Aparna Mukhopadhyay Robert F. Mullins William Alexander Munoz Dorothee Murat Neal C. Murphy Amanda Murray Sushmita Mustafi Kaori Nagao Tadahiro Nagaoka Shirisha Nagotu Yuko Nakajima Ayaki Nakamoto Joji Nakayama Kerry-Ann Nakrieko Jin-Min Nam Sang-Chul Nam Abed Namavari

Yuichi Namba Rajalakshmi Nambiar Kyster K. Nanan Jordan J. Nance Dorit Naot Johanna Napetschnig Isaac Nardi Keishi Narita Ritsuko Nasu Deanna Marie Navaroli Pavel I. Nedvetsky Thomas Edward Neill Elke S. Nelson Shane Nelson Nicole Amanda Neuman Laura L. Newcomb Cuong Quoc Nguyen Hoang-Lan Nguyen Nghi Khanh Nguyen Quang Xuan Nguyen Trang Thuy-Huu Nguyen Anthony Vincent Nicola Matt Jeffrey Niederst Yoshii Nishino Robert Michael Nissen Hidehiro Nomura Stephanie Nowotarski Evelyne E. Ntam Ashleigh E. Nugent Surawej Numhom Daniel Nunez Miklos Nyitrai Todd Nystul Blake Robert Obrock Amber Kathleen O’Connor Hiroyo Oda Allyson Faye O’Donnell Margit Oelkers Carolin Offenhäuser Yetunde Ogunkoya Bora Oh Yuko Ohira Maikke Beyer Ohlson Yoshimi Ohyabu Kohki Okabe Yohei Okada Takaharu Okajima Chieme Kennedy Okechukwu Chinweike F. Okegbe Joan Oliva Anique Julienne Olivier-Mason Sara Olson E-Ching Ong Yasuhito Onodera Michael T. Onwugbufor Kassandra Marie Ori-McKenney Brian Patrick O’Rourke Stephan Ort Takanori Otomo Miki Otsuki Christopher John Ott Yingshi Ouyang Michael Overholtzer Daniel Arap Oyugi Anup Padmanabhan Glorivee Pagan-Mercado Sushmita Pahari Chockalingam Palaniappan Amy Elizabeth Palmer Katia Sabrina Paludo Allison J. Pang Mei-Fong Pang Kanokwan Panyayong Alexander R. Paredez Aron Parekh Loukia Parisiadou Chan Young Park Chang Wook Park Choon-sik Park Joo-Won Park Jung-Eun Park Seong Hwan Park Yong-Yea Park George Parker Rebecca D. Parr Alberto Parra

Anuj Ashwin Patel Yashomati Mulchand Patel Kimagesha Lakeisha Patrick Parag P. Patwardhan Maly Sebastien Paul Raja Paul Virginia Pearce Jacques Pecreaux Tsafi Pe’ery John Culver Pelton Christiane Pelz Cai Peng Xiao Peng Christopher A. Pennell Meenu Nadisha Perera Pablo Perez-Pinera Alexandros Pertsinidis Giovanna Peruzzi Isabel Peset Martin Patrizia Pessina Nikolay B. Pestov Christopher W. Peterson Ryan Petrie Sabine Petry Emily Pfeiffer Shona Louisa Pfeiffer Cathie Michelle Pfleger Tan-Trao Phi Bryan Phillips Alain Piché Alison Pidoux Erika Sofia Piedras-Renteria Francisco Javier Pina Jaimie Maria Pineda José R. Pineda Decha Pinkaew Carina Esteves Pinto Melissa S. Pischke Elzbieta Pluskota Steve Poirier Pichaya Pojanapotha Tatyana Polenova Markeiya T. Polite Arturo Ponce Jesse Popov Nathan Portier Scott Michael Portwood Maxim Poustovoitov Maria Cristina Da Silva Pranchevicius Nagendra K. Prasad Sai Han Presley Alivia Lee Price Jennifer Procopi Catia C. Proenca Ivan Prokudin Margaret Pruitt Thomas John Pucadyil Praveen Pudiavettil Tayakuniyil Jesse Punch Enkhtsetseg Purev Shao Cindy Qing Ping Qiu Lishu Qu Christopher M. Quick Quincy Antoine Quick Frederick D. Quinn Lilliana Charlotte Radoshevich Hanania Raed Zohra Rahmani Vandana Rai Raquel Marie Raices Tina Rajabian Gunaretnam Rajagopal Vinay Ramabhadran Sreekumar Ramachandran Srinivasan Ramachandran Joseph Samarah Ramahi Maya Ramdas Natalie Ramsey Manish Kumar Rana Giulia I. Rancati Aghdass Rasouli-Nia Amanda Patrice Rawson Joseph Rayman Chiara Recchi Shawna C. Reed

Esther Reefman Angela Michele Reevely Adam Reinhart David Anthony Rempe Yixin Ren Lindsay Anne Reustle Chetana Revankar Adriana Reyes-Gonzalez Soyoung Rhee Nick Rhind Susana Abreu Ribeiro Sara Ricardo Douglas Richardson Constance Richter Paula Rickert Derek Ricketson Lee Rickords Regina Rillo Brandon Charles Rindfleisch Manuel Antonio Riquelme Benjamin Joseph Ritchie Marielis E. Rivera Kevin Ro Kevin Roach David John Rodda Monica Carolina Rodrigo Brenni Marbelys Rodriguez Imilce A. Rodriguez-Fernandez Alejo E. Rodriguez-Fraticelli Jared Todd Roeckner Luis A. Rokeach Gustavo A. Romero-Perez Dorit Ron Ze’ev Ronai Ola Ronn Thomas Roos Andre Dwayne Rosario Anton I. Rosenbaum Boryana Rossenova Maria Isabel Doria Rossi Jacquelyn Jinan Roth Ross William Stanley Rounsevell Breton Roussel Debarshi Roy Sanhita Roy Srirupa Roy Dan Rozelle Agrani Rump Zeid Rusan Katie Ryan Sanaz Saatchi Alessandra Sacco Navdeep Kaur Sahota Koji Saito Satoko Sakamoto Amy Saldana Tavares Renato Mayrinck Salgado Emma Salomonsson Erik Robert Sampson Javier Arturo Sánchez-López Raudel Sandoval Jayanthi Sanjeevi Narendra V. Sankpal Silvia DM Santos Thatiana Mara Santos Zita Carvalho Santos Jacob Sapiro Smita Sarkar Nobunari Sasaki Terry Sasser Noboru Sato Noboru Sato Katherine Elizabeth Saul Julia Schaletzky Christine Elizabeth Schaner Tooley Johanna Schaub Lea Luana Scheffer Antonino Schepis Jennifer Michelle Schieltz Sabrina Schlie Kathrin Schloen Eva Maria Schmid Kristopher Lee Schmidt Kurt Michael Schmoller Joseph M. Schober

ASCB NEWSLETTER JANUARY 2009

Andre Schönichen Timothy J. Schrader Alexander Schreiner Ryan Schreiner Harry (Trey) W. Schroeder Sebastian Schuck Rebecca Schulman Mara Schvarzstein Cindi Lynn Schwartz Geoffrey Bryant Schwartz Thomas U. Schwartz Brett Robert Scipioni Paula B. Scotland Jakub Sedzinski Jack L. Segal Marion Segalen Jessica RK Seifert Tracie Seimon Sheila Semaan Oksana Andrei Sergeeva Claudio Sette Marion B. Sewer Mehdi Hayat Shahi Shahab Shahnazari Jay Shankar Igor V. Sharakhov Maryam Shariati Kshitija Sharma Judith A. Sharp Rebecca Sheller Hongying Shen Nina Tang Sherwood Jiahai Shi S. Brookhart Shields David Andrew Shifrin Yi-Ping Shih Soomin Shim Michelle Shimogawa Ilchung Shin Jessica Marshall Shivas Kenji Fabricio Shoji Laura Shum Maria Shutova Shadab A. Siddiqi Christina Lynne Siewit William Silkworth Steve Silletti Andrew Simmonds Dan Simon Brittany Simone Veena Singla Sushama Sivakumar Christina Marie Sloan Cynthia Smas Pliny A. Smith Tasha Semoine Smith Adam Karl Snider Ksenia Sniegowski Kathy J. Snow Brandi Snyder Christopher So Maria Albertina De Miranda Soares Kevin Soe Jim Kim U. Soh Yunjo Soh Sarah Soliman Dmitry A. Soloviev Yong-Hae Son Jeong Kuen Song Jeongmin Song Lee Soon-duck Virupakshi Soppina Erika B. Sorensen Adriana Soto-Guzman Daniel R. Southworth Lorena Brito Souza Joachim P. Spatz

Erin Irene Spicer Annina Constanze Spilker Kimberly Ann Spurgeon Kalyan Srivastava Scott Stagg Jennifer Anne Stanley Mark William Staudt Michel Steinmetz Alexandre Stephens Deanna Stevens Helen Elizabeth Margaret Stimpson Peter Cameron Stirling Craig Michael Story Daniel Kenneth Stringer Danielle Marie Stringer Matthew John Stroud William Dorsey Stuart Karla M. Stucker Jing Su Shih-Chi Su Pakpoom Subsoontorn Haixin Sui Anna L. Sukhanova Anupam Ashutosh Sule Yvonne Bauer Sullivan Luo Sun Qian-Quan Sun Shangjin Sun Ying Sun Yuting Sun Mark Scott Sundrud Kevin Michael Sunley James David Sutherland Madoka Suzuki Vinay Swaminathan Jeremy Aaron Swan Kristin Renae Sweeney Saiful Effendi Syafruddin Michael Andrew Stanley Taboski Mitsuaki Tabuchi Lungkuo Tai Pekka Taimen Senye Takahashi Toshiaki Takahashi Lauren Michele Tanabe Sabrina Beliz Taner Lisa Anne Taneyhill Carolina Inga Louise Tangemo Masahiro Tanji Kandice Tanner Erin Christine Tapley Surayya Taranum Etsu Tashiro Ryuichi Tatsumi David Richard Taylor Kristi M. Teal Justus Tegha Dunghu Arnaud Teichert Yanfen Teng Rebeca Tenney Chin-Fen Teo Carmen Teodorof Jonathan R. Terman Whitney Tevebaugh Bastian Thaa Subhash Thalappilly Niramon Thamwiriyasati Kwanta Thansa Binu Tharakan Mia Mia Thi Nisha Elizabeth Thomas Tamlyn Thomas Candice N. Thompson Kalyani Thyagarajan Kim Tieu Muyideen Tijani

JANUARY 2009 ASCB NEWSLETTER

Rakeb Abbay Tilahun Aaron R. Tipton Mariana G. Todorova Daisuke Tohyama Alejandra Tomas Xin Tong Vicente A. Torres Viviana Isabel Torres Katharine Toth Cristy Darette Tower Slavica Trajikovska John Tran Tiffany Tran Daniel M. Trindade Carolina Tropini Agnieszka Dorota Truax PeiChin Tsai Tony Tsai Yu-Chen Tsai Yu Chung Tse Joseph Ta-Chien Tseng Kuo-Fu Tseng Masanao Tsuda Toshiya Tsuji Ya-Ting Tu Nathan R. Tucker Shanshan Tuo Patrick Turmel Hannah Hewitt Tuson Himani Tyagi Randall Geddes Tyers Ryan Edward Tyler George Tzircotis Takayuki Ueno Theresa A. Ulrich Taehee Um Shinjiro Umezu Julie Underwood James Uniacke Ercan Selcuk Unlu Takeshi Urano Deirdre Vaden Alex Mihkel Valm David Wallace Van De Vosse Rukiyah T. Van Dross Janine H. Van Ree David A. Van Valen Kristyn VanderWaal Athanasios Vasilopoulos Shobha Vasudevan Paolo Vatta Joshua Vaughan Mandana Veiseh Cristina Amada Velez-del Valle Ryan M. Vellinga Gautham Venugopalan Joshua A. Vieth Leena Vig Elizabeth Villa Emilie Vinolo Valeria Viscardi Jason Vitko Cristofol Vives-Bauza Vladimir A. Volkov John Vu Mariaana Virve Vuoriluoto Subhagya Ashok Wadekar Ashar Wadoodi Purnima Wagh Nicole M. Wakida Elyse Walk David Walter Aibing Wang Chaoyang Wang Hehai Wang I-Hsuan Wang Jin-Hee Wang Ju-Ming Wang

Lingyan Wang Ling-yu Wang Meng Wang Mengqiao Wang Nengding Wang Qi Wang Qinchuan Wang Qingjun Wang Renjing Wang Songyu Wang Xiaoqun Wang Megan Marie Wargacki Wayne A. Warner Leah Watson Kolja Alexander Wawrowsky Lesley Nicole Weaver Brian L. Webb Kevin Webster Mei Wei Qiaozhi Wei Jimena Weibezahn Kimberly Nicole Weiderhold Jasper Stanley Weinberg Julie PI Welburn Adrienne Wells Yi-Chinn Weng Adam Werts Kristin Wescoe Naama Wiesel Motiuk Jeffrey Wigle Jeremy Wilbur Grzegorz Wilczynski Linda Wildling Mandi Wiley Dumaine Williams Jason S. Williams Jeffrey W. Williams Christopher Garrison Wilson Sarah Lynn Windler Joerg E. Wissler Stephan N. Witt Helena Wojciechowski Julie Marie Wolf Kam Wai Wong Naikei Wong Younhi Woo Yvonne J. Woolwine David Wu Haiming Wu Hao Wu Jui-ching Wu June-Tai Wu Mingfu Wu Pei-hsun Wu Martin Helmut Wuehr David J. Wynne Charles Peter Xavier Jun Xia Yougui Xiang Meifang Xiao Xue Xiaoxiao Ce Xie Zhiping Xie Zhongjian Xie Zheng Xing Fei Xiong Jielin Xu Jinchong Xu Ming Qun Xu Weibin Xu Ajay Kumar Yadav Yuichi Yagita Ai Yamamoto Takaharu Yamamoto Run-Tao Yan Hyun Yang Jin-Long Yang Shi Yu Yang

Yixin Yang Youn-Joo Yang Yuqing Yang Thomas Yann Changfu Yao Gang Yao Yong Yao Travis James Yates Karen Kar Lye Yee Chunyue Yin Lei Yin Xing Yin Hideki Yokoyama Jeong Eun Yoo Kyung Won Yoon Takeshi Yoshida Azumi Yoshimura Ran You Hong-Duk Youn J’Nelle Sarah Young Chi-Yi Yu Tao Yu Guillermo A. Yudowski Ivan A. Yudushkin Karen Wing Yee Yuen Jiwon Yun Junsoo Yun Syed M. Zaidi Allison Lorraine Zajac Marija Zanic Sotirios Zarogiannis Francisco Jose Zayas Frank Zeigler Cui Jing (Tracy) Zeng Lanying Zeng Shuxin Zhan Chang-liang Zhang Hao Zhang Huizhen Zhang Li Zhang Shaobing Zhang Tong Zhang Yali Zhang Yueqiang Zhang Yueting Zhang Zhao Zhang Zhonghua Zhang Ping Zhao Xiaoqing Zhao Yuting Zhao Guo Zhen Yen-Yi Zhen Lei Zhong Zhixia Zhong Bo Zhou Wenke Zhou Zheng Zhou Jie Zhu Jinhong Zhu Joshua Willem Ziel Michael Zimber Seth Parker Zimmerman Brandon Zipp Xianqiong Zou Nikolaj Zuleger

Members Granted Emeritus Status Winston Anderson Eve Barak Kenneth Brunson David Epel Michael Glaser Margaret Lomax Jurgen Roth Christopher Watters

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GRANTS & OPPORTUNITIES HHMI Postdoctoral Fellowships. Howard Hughes Medical Institute will partner with the Jane Coffin Childs Memorial Fund, Helen Hay Whitney Foundation, Damon Runyon Cancer Research Foundation, and Life Sciences Research Foundation to fund 16 annual fellowships to help advance young scientists. www.hhmi.org/news/20070604postdoc.html. National Centers for Biomedical Computing (R01). This funding opportunity is for projects from individual investigators or small groups to collaborate with the NIH Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs). Collaborating projects are intended to engage researchers in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. Expiration: September 8, 2011. http://grants.nih.gov/grants/guide/pa-files/PAR-08-184.html. NIGMS Grants. The National Institute of General Medical Sciences is accepting applications for funding research in which several interdependent projects offer significant advantages over support of these same projects as individual research. Standard NIH application dates apply. http://grants.nih.gov/grants/guide/pa-files/PA-07-030.html. NIH Administrative Supplements for Induced Pluripotent Stem Cell Research. The National Institute of General Medical Sciences, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and the National Eye Institute announce the availability of one-year administrative revisions (also referred to as supplements) for funded grantees to encourage research into the derivation, characterization, and/or utilization of induced pluripotent stem cells (iPS) from non-embryonic sources. Application receipt date: April 1, 2009. http://grants.nih.gov/grants/guide/notice-files/NOT-GM-08-136.html. NIH CSR Marcy Speer Award. The Marcy Speer Award recognizes scientists who demonstrate extraordinary commitment to NIH Center for Scientific Review peer review groups, making it possible for NIH to fund the best applications and, ultimately, improve public health. The next nomination deadline is April 16, 2009. http://cms.csr.nih.gov/AboutCSR/SpeerAward.htm. NIH OPASI Transformative R01 Program. The NIH Office of Portfolio Analysis and Strategic Initiatives, which houses the NIH Director’s Roadmap for Medical Research, has announced a new Transformative R01 Program in support of investigator-initiated research that proposes to disrupt currently existing paradigms or create new ones where none exist. Application receipt date: January 29, 2009. http://nihroadmap.nih.gov/T-R01. NIH Administrative Supplements for Induced Pluripotent Stem Cell Research. The National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases, and National Eye Institute announce the availability of one-year administrative revisions (also referred to as supplements) for funded grantees to encourage research into the derivation, characterization, and/or utilization of induced pluripotent stem cells (iPS) from non-embryonic sources. This opportunity replaces NOT-NS-08-013, NIH Administrative Revisions for Human Pluripotent Stem Cell (hPSC) Research Using Non-Embryonic Sources, which was announced January 17, 2008. Formal requests must be received on or before April 1, 2009. NRSA Awards. The NIH Agency for Healthcare Research and Quality is accepting applications for the Ruth L. Kirschstein National Research Service Awards. The predoctoral fellowships promote diversity in health-related research. Application deadlines are May 1 and November 15 through 2009. http://grants1.nih.gov/grants/guide/pa-files/PA-06-481.html#SectionI. NRSA Research Training Grant. The National Institute of General Medical Sciences will award MARC U-STAR National Research Service Act grants to minority-serving institutions that support undergraduate biomedical and behavioral research. Application deadline is May 25, 2009. http://grants.nih.gov/grants/guide/pa-files/PAR-07-337.html. Research Supplements to Promote Diversity in Health-related Research. These supplements are intended to promote diversity in the biomedical, behavioral, clinical, and social sciences research workforce. Expiration: September 30, 2011. http://grants.nih.gov/grants/guide/pa-files/PA-08-190.html.

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ASCB NEWSLETTER JANUARY 2009

GRANTS & OPPORTUNITIES Research Supplements to Promote Re-entry into Biomedical and Behavioral Research Careers. These supplements are intended to encourage individuals to re-enter research careers within the missions of all NIH program areas. This program will provide administrative supplements to existing NIH research grants to support full-time or part-time research by individuals in a program geared to bring their existing research skills and knowledge up-to-date. Expiration: September 30, 2011. http://grants.nih.gov/grants/guide/pa-files/PA-08-191.html. RISE (Research Internships in Science and Engineering) and RISE Professional Programs. The German Academic Exchange Service (DAAD) offers scholarships to American and Canadian students to work on cutting-edge research projects at top research institutions (e.g., Max-Planck-Institutes) and universities in Germany. 2009 deadline for undergraduates: January 31, 2009. www.daad.de/rise. SCORE Awards. The National Institute of General Medical Sciences is accepting applications for its Support of Competitive Research (SCORE) developmental awards designed to increase faculty research competitiveness at minority-serving institutions. Multiple deadlines through May 18, 2010. The program announcement, as well as three other program announcements (PAR-06-491, PAR-06-492, PAR-06-493), can be found at http://grants1.nih.gov/ grants/guide/pa-files/PAR-06-490.html#PartI. n

JANUARY 2009 ASCB NEWSLETTER

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MEETINGS Calendar ASCB

Annual Meetings 2009 San Diego December 5–9 2010 Philadelphia December 11–15 2011 Denver December 3–7 2012 San Francisco December 15–19 2013 New Orleans December 14–18 2014 Philadelphia December 6-10

February 28–March 4, 2009. Boston, MA Biophysical Society 53rd Annual Meeting. www.biophysics.org/ 2009meeting. March 4–8, 2009. Chicago, IL Genetics Society of America: 50th Annual Drosophila Research Conference. www.drosophila-conf. org/2009. March 7–11, 2009. Charleston, SC American Society for Neurochemistry 2009 Annual Meeting. http:// asneurochem.org/2009Meeting/ ASN2009.htm. March 17–22, 2009. Pacific Grove, CA Genetics Society of America: 25th Fungal Genetics Conference. www. fgsc.net/25thFGC/FGC25.htm. April 13–24, 2009. Biopolis, Singapore European Molecular Biology Organization and Institute of Medical Biology Course: FRET, FLIM, FCS, FRAP and 3-D Imaging—Application to Cell and Developmental Biology. http://cwp.embo.org/wpc09-01.

8120 Woodmont Avenue Suite 750 Bethesda, MD 20814-2762

May 3–7, 2009. Fort Lauderdale, FL Association for Research in Vision and Ophthalmology 2009 Annual Meeting: Reducing Disparities in Eye Disease and Treatment. www.arvo.org/eweb/ startpage.aspx?site=AM2009.

July 4–9, 2009. Prague, Czech Republic 34th Congress of the Federation of European Biochemical Societies: Life’s Molecular Interactions. www.febs2009.org.

May 24–27, 2009. Xiamen, China Wnt Signaling, Organogenesis, and Stem Cells Conference. http://life. xmu.edu.cn/wntmeeting/index.htm.

July 19–24, 2009. New London, NH Gordon Research Conference, Cell– Cell Fusion. www.grc.org/programs.as px?year=2009&program=cellcell.

May 27–29, 2009. Charlottesville, VA 4th Biennial Morphogenesis and Regenerative Medicine Symposium www.morphogenesis.virginia.edu/ index.htm.

July 23–27, 2009. San Francisco, CA Society for Developmental Biology 68th Annual Meeting. www.sdbonline. org/2009Mtg/Webpage.htm.

June 4–6, 2009. Toronto, Canada Organization for the Study of Sex Differences Third Annual Meeting. www.ossdweb.org/mc/page. do?sitePageId=64130. June 14–18, 2009. Zürich, Switzerland VIII European Symposium of The Protein Society. www.proteinsociety.org.

August 29–September 1, 2009. Amsterdam, The Netherlands The EMBO Meeting 2009. www.the-embo-meeting.org. September 3–7, 2009. Cambridge, England Strategies for Engineered Negligible Senescence (SENS), 4th Conference. www.mfoundation.org/sens4. September 5–8, 2009. Visegrád, Hungary 12th European Meeting on Complement in Human Disease. www.chd2009.com. n

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